From the Guidelines
No, Avil is not chlorpheniramine maleate. Avil is the brand name for pheniramine maleate, which is a different antihistamine medication. Both drugs belong to the first-generation antihistamine class and work by blocking histamine H1 receptors to relieve allergy symptoms, but they are distinct chemical compounds. Pheniramine maleate (Avil) is commonly used to treat allergic conditions like hay fever, urticaria, and allergic rhinitis, providing relief from symptoms such as sneezing, itching, and watery eyes. Chlorpheniramine maleate is sold under different brand names such as Chlor-Trimeton or Allerchlor. While both medications have similar side effect profiles including drowsiness, dry mouth, and blurred vision, they are prescribed at different dosages and may be chosen based on individual patient response and specific allergic conditions being treated. The use of antihistamines like pheniramine maleate and chlorpheniramine maleate is supported by studies such as 1, which discusses the role of antihistamines in treating anaphylaxis and other allergic reactions, highlighting their effectiveness in relieving cutaneous signs and symptoms. However, it's crucial to note that these medications should not be used as a replacement for epinephrine in the treatment of anaphylaxis, as emphasized in 1. Key points to consider when prescribing Avil (pheniramine maleate) or chlorpheniramine maleate include:
- Their classification as first-generation antihistamines
- Their mechanism of action as H1 receptor blockers
- Their use in treating allergic conditions
- Their side effect profiles
- The importance of not using them as a substitute for epinephrine in anaphylaxis treatment, as discussed in 1.
From the FDA Drug Label
Active ingredient (in each tablet) Chlorpheniramine maleate 4 mg The answer is yes, Avil is chlorpheniramine maleate 2.
From the Research
Avil Composition
- Avil is a medication that contains chlorpheniramine maleate as one of its active ingredients 3, 4, 5, 6, 7.
Chlorpheniramine Maleate Properties
- Chlorpheniramine maleate is a first-generation H1 antihistamine that has been used since the 1950s to treat allergic conditions, including common colds and coughs 4.
- It is available in various forms, including oral, intravenous, intramuscular, and subcutaneous routes, and has recently been explored for intranasal use due to its antiviral properties against SARS-CoV-2 4.
Avil Uses
- Avil, containing chlorpheniramine maleate, is commonly used to treat symptoms of the common cold, such as sneezing, runny nose, and itchy eyes 3, 7.
- Chlorpheniramine maleate has also been studied for its potential use in treating other conditions, including asthma, plasma cell gingivitis, chronic urticaria, and depression 4.
Safety and Efficacy
- Studies have shown that chlorpheniramine maleate is generally safe and effective in relieving symptoms of the common cold, with minimal side effects 3, 7.
- However, rare cases of anaphylaxis to chlorpheniramine maleate have been reported, highlighting the importance of careful diagnosis and treatment 5.