From the Guidelines
The trade name for polyethylene glycol 3350 (PEG 3350) is MiraLAX in the United States, though it's also marketed under other brand names such as GlycoLax, ClearLax, and GaviLAX. This medication is an osmotic laxative commonly used to treat occasional constipation and for bowel preparation before certain medical procedures. PEG 3350 works by drawing water into the colon, which softens the stool and increases bowel movements, as studied in multiple randomized, placebo-controlled trials, including one published in 2023 1. It typically comes as a powder that is dissolved in liquid and taken orally. The standard adult dose is 17 grams (about 1 heaping tablespoon) dissolved in 4-8 ounces of water or other beverage once daily, as approved by the FDA for the treatment of occasional constipation 1. PEG 3350 is generally well-tolerated because it is not absorbed into the bloodstream and works locally in the intestines. It usually produces a bowel movement within 1-3 days of starting treatment. Unlike stimulant laxatives, PEG 3350 doesn't cause cramping and is considered safe for short-term use, though patients should consult healthcare providers before using it for extended periods. Key benefits of PEG 3350 include its efficacy in increasing bowel movements, improving stool form, and reducing straining, as demonstrated in clinical trials 1.
Some of the key points to consider when using PEG 3350 include:
- It is available over-the-counter (OTC) and is relatively inexpensive 1
- It has been shown to be efficacious in individuals with chronic idiopathic constipation (CIC) for up to 6 months 1
- It has a similar or greater efficacy compared to other medications such as tegaserod, prucalopride, and lactulose in individuals with CIC 1
- Common side effects include bloating, flatulence, and diarrhea, but these are typically mild or moderate 1
From the Research
Trade Name for Polyethylene Glycol 3350
The trade name for polyethylene glycol 3350 (PEG 3350) is:
Key Points
- PEG 3350 is used for the treatment of constipation in adults and children 2, 3, 4, 5, 6
- The recommended dose is 17 g once daily 3, 4, 6
- PEG 3350 is safe and effective for short-term and long-term use 3, 4
- It is available over-the-counter (OTC) and can be recommended by pharmacists for managing constipation 6