From the Guidelines
Yes, GLP-1 receptor agonists like Ozempic (semaglutide) can cause physical fatigue and mental drowsiness in some patients. These side effects are relatively common, particularly during the initial weeks of treatment or after dose increases. Fatigue affects approximately 10-20% of patients taking these medications, while drowsiness or mental fogginess is reported less frequently but still occurs. These symptoms often improve over time as the body adjusts to the medication. The fatigue may be related to several factors, including the medication's effects on slowing gastric emptying, potential mild dehydration from increased urination, reduced caloric intake, or the body's adaptation to metabolic changes. If experiencing severe fatigue or drowsiness that interferes with daily activities, patients should stay well-hydrated, ensure adequate nutrition despite reduced appetite, maintain regular physical activity as tolerated, and consider taking the medication before bedtime if approved by their healthcare provider. If symptoms persist or worsen, patients should consult their healthcare provider, who might adjust the dosing schedule or recommend supportive measures rather than discontinuing this beneficial medication class 1.
Some key points to consider when taking GLP-1 receptor agonists like Ozempic include:
- Gradual dose titration to minimize gastrointestinal adverse effects, as recommended for semaglutide and liraglutide 1
- Monitoring for adverse effects such as nausea, vomiting, diarrhea, headache, weakness, or dizziness, as reported in studies 1
- Considering the potential benefits of GLP-1 receptor agonists in reducing cardiovascular risk and improving glycemic control, as demonstrated in clinical trials 1
- Weighing the risks and benefits of continuing or discontinuing GLP-1 receptor agonists in the peri-operative period, given the potential for gastric stasis and aspiration or regurgitation 1
Overall, while GLP-1 receptor agonists like Ozempic can cause physical fatigue and mental drowsiness, these side effects can often be managed with supportive measures and dose adjustments, and the benefits of these medications can outweigh the risks for many patients.
From the FDA Drug Label
Fatigue, Dysgeusia and Dizziness Other adverse reactions with a frequency of >0.4% were associated with OZEMPIC include fatigue, dysgeusia and dizziness.
Yes, GLP-1 receptor agonists like Ozempic (Semaglutide) can cause physical fatigue and mental drowsiness is not explicitly mentioned, but dizziness is, which may be related to mental drowsiness. Key points:
- Fatigue is listed as an adverse reaction associated with Ozempic.
- Dysgeusia (distortion of the sense of taste) and dizziness are also listed as adverse reactions. 2
From the Research
GLP-1 Receptor Agonists and Fatigue
- GLP-1 receptor agonists like Ozempic (Semaglutide) have been studied for their effects on various aspects of health, but there is limited direct evidence on their impact on physical fatigue and mental drowsiness.
- A study from [@\5@] discusses the adverse effects of GLP-1 receptor agonists, mentioning common symptoms such as nausea, injection site reactions, headache, and nasopharyngitis, but does not specifically address physical fatigue or mental drowsiness.
Gastrointestinal Symptoms and Potential Fatigue
- The study [@\1@] describes a case where a patient on Ozempic developed appendicitis, highlighting gastrointestinal adverse effects associated with GLP-1 RAs. While this does not directly address fatigue, severe gastrointestinal symptoms could potentially contribute to feelings of fatigue.
- Another study [@\3@] reports on unintentional semaglutide overdoses, resulting in nonspecific gastrointestinal symptoms. Again, this does not directly mention fatigue but suggests that gastrointestinal issues could be a factor.
Metabolic Effects and Potential Impact on Fatigue
- A clinical trial protocol [@\4@] investigates the effects of semaglutide on metabolic disturbances in patients with schizophrenia spectrum disorders. While this study focuses on metabolic outcomes, improvements in metabolic health could indirectly influence energy levels and fatigue.
Conclusion on Available Evidence
- There are no direct research papers among the provided evidence that specifically address whether GLP-1 receptor agonists like Ozempic cause physical fatigue and mental drowsiness. The available studies focus on gastrointestinal symptoms, metabolic effects, and other adverse events associated with GLP-1 RAs, without explicitly discussing fatigue or drowsiness [@\1@, @\2@, @\3@, @\4@, @\5@].