From the Guidelines
Bently cannot be used as needed (prn) for symptom management as there is no evidence to support its use in this context. Instead, several medications can be used as needed (prn) for symptom management, including antispasmodics, anti-diarrhoeals, and laxatives. Common prn medications include:
- Loperamide 4-12 mg daily for diarrhoea 1
- Antispasmodics, such as hyoscine, for abdominal pain 1
- Osmotic laxatives, such as polyethylene glycol, for constipation 1
- Secretagogues, such as linaclotide or plecanatide, for constipation 1
- Tricyclic antidepressants, such as amitriptyline, for abdominal pain 1 When using prn medications, it's essential to track symptoms, timing, and effectiveness to help determine if a scheduled regimen might be more appropriate. These medications work through various mechanisms, including reducing pain perception, blocking neurotransmitters that trigger nausea, and enhancing inhibitory GABA effects in the brain. Always follow specific dosing instructions from your healthcare provider, as individual needs vary based on age, weight, kidney/liver function, and other medications 1.
From the FDA Drug Label
The FDA drug label does not answer the question.
From the Research
Medications for Symptom Management
The question of whether Bently can be used as needed (prn) for symptom management does not have a direct answer in the provided studies, as there is no mention of a medication called "Bently". However, the studies do discuss various medications that can be used for symptom management in irritable bowel syndrome (IBS).
Medications for IBS Symptom Management
Some medications that can be used for IBS symptom management include:
- Loperamide, which seems efficacious for diarrhea 2, 3, 4, 5
- Ispaghula, which may be used for constipation 2
- Musculotropic spasmolytics, which may relieve abdominal pain 2
- Antidepressants, which may be efficacious for abdominal pain, but their tolerance may be problematic 2, 3, 6, 5
- Lubiprostone, a chloride channel activator, which showed favorable effects on multiple symptoms in IBS with constipation 2, 3
- Linaclotide, a guanylyl cyclase-C agonist, which showed favorable effects on multiple symptoms in IBS with constipation 2, 6
- Rifaximin, a poorly absorbable antibiotic, which showed efficacy in phase III trials in IBS-D and was approved by the FDA 2
- Eluxadoline, a mu opioid receptor agonist and delta antagonist, which showed efficacy in phase III trials in IBS-D and was approved by the FDA 2
- Probiotics, which may provide benefit for IBS symptoms 3, 6, 4
Use of Medications as Needed (prn)
While the studies do not specifically discuss the use of medications as needed (prn) for symptom management, they do provide information on the efficacy of various medications for IBS symptoms. It is likely that some of these medications could be used as needed for symptom management, but this would depend on the specific medication and the individual patient's needs.