What is the differential diagnosis for Upper Respiratory Tract Infection (URTI)?

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Last updated: February 26, 2025View editorial policy

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Differential Diagnosis for URTI

  • Single Most Likely Diagnosis
    • Viral upper respiratory tract infection (e.g., common cold): This is the most common cause of URTI symptoms, such as runny nose, cough, and sore throat, and is usually self-limiting.
  • Other Likely Diagnoses
    • Bacterial pharyngitis (e.g., strep throat): Presents with sore throat, fever, and swollen lymph nodes, and requires antibiotic treatment.
    • Sinusitis: Inflammation of the sinuses, often caused by bacterial or viral infection, presenting with facial pain, nasal congestion, and purulent discharge.
    • Allergic rhinitis: An allergic reaction to airborne allergens, causing symptoms such as sneezing, runny nose, and itchy eyes.
  • Do Not Miss Diagnoses
    • Epiglottitis: A potentially life-threatening infection of the epiglottis, requiring prompt medical attention, presenting with severe sore throat, difficulty swallowing, and shortness of breath.
    • Peritonsillar abscess: A collection of pus behind the tonsils, requiring drainage and antibiotic treatment, presenting with severe sore throat, fever, and difficulty swallowing.
    • Lemierre's syndrome: A rare but serious condition caused by bacterial infection, presenting with sore throat, fever, and neck pain, which can lead to sepsis and other complications.
  • Rare Diagnoses
    • Infectious mononucleosis: A viral infection caused by Epstein-Barr virus, presenting with sore throat, fever, and lymphadenopathy.
    • Diphtheria: A rare but serious bacterial infection, presenting with sore throat, fever, and a characteristic membrane covering the tonsils and throat.
    • Tuberculosis: A rare cause of URTI symptoms, presenting with chronic cough, fever, and weight loss, requiring prompt medical attention and treatment.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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