From the Guidelines
The CDC recommends that patients with COVID-19 should follow home isolation guidance, waiting a minimum of 10 days after symptom onset, along with fever resolution for 24 hours without antipyretics and improvement in other symptoms, before ending home isolation and returning to work 1. When it comes to quarantine and treatment, the CDC guidance is crucial for managing COVID-19, especially in patients with underlying conditions like psoriatic disease.
- The guidance emphasizes the importance of evidence-based COVID-19 therapies, including supportive care for all patients and specific treatments like dexamethasone, remdesivir, and baricitinib for hospitalized patients meeting specific criteria 1.
- For outpatients, treatments such as bamlanivimab and casirivimab plus imdevimab are recommended for patients at high risk of progressing to severe COVID-19 and/or hospitalization 1.
- Systemic corticosteroids are not contraindicated in patients with psoriatic disease and should not be withheld due to concerns about potentially flaring psoriasis upon withdrawal 1.
- Hydroxychloroquine, chloroquine, and ivermectin are not recommended for the prevention or treatment of COVID-19 outside of a clinical trial 1.
- Patients with close contact to someone with SARS-CoV-2 infection should quarantine themselves for 14 days after the last contact and discuss the management of their psoriatic disease treatment with their medical provider(s) 1. It is essential to follow CDC guidance on home isolation and quarantine to prevent the spread of COVID-19 and to seek medical attention immediately if emergency warning signs occur 1.
From the FDA Drug Label
The FDA drug label does not answer the question.
From the Research
CDC Recommendations for Covid-19 Quarantine
- The CDC recommends that persons who have been in close contact with someone with SARS-CoV-2 infection should quarantine for 14 days after the last known contact 2.
- However, the CDC also recommends two options to reduce the duration of quarantine for close contacts without symptoms:
- Quarantine can end on day 10 without a test.
- Quarantine can end on day 7 after receiving a negative test result 2.
Treatment of Covid-19
- Nirmatrelvir with ritonavir (Paxlovid) is indicated for patients with COVID-19 who are at risk for progression to severe disease due to the presence of one or more risk factors 3.
- Paxlovid was highly effective at preventing hospitalization and death in clinical trials, and real-world data suggests it reduces the risk of hospitalization by 39% and the risk of death by 61% 3.
- Early combination therapy with remdesivir, nirmatrelvir/ritonavir, and sotrovimab may be effective in immunocompromised patients, with 100% of patients reaching virological clearance when treated in the early phase of COVID-19 4.
Quarantine Period
- A longer quarantine period may be needed for effective control of COVID-19 transmission, with one study suggesting that 84.7% of cases had an incubation period of more than 14 days 5.
- Another study found that exposed asymptomatic students ages 18-44 years in a university setting are at low risk if released from quarantine at 7 days if they test negative PCR test prior to release 6.