What is the cause of postpartum (post-delivery) extreme fatigue with normal mood?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: February 26, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnosis for Extreme Tiredness Post-Delivery

Single Most Likely Diagnosis

  • Postpartum fatigue: This is the most common cause of tiredness post-delivery, often due to sleep deprivation, hormonal changes, and the physical demands of caring for a newborn. The fact that moods are reported as okay suggests that this might be more related to physical exhaustion rather than a mood disorder.

Other Likely Diagnoses

  • Anemia: Common in postpartum women, especially if there was significant blood loss during delivery. Anemia can cause extreme tiredness.
  • Thyroid dysfunction: Postpartum thyroiditis can occur and may present with fatigue, among other symptoms.
  • Sleep disorders: Sleep apnea or insomnia can significantly contribute to tiredness and are not uncommon in the postpartum period.
  • Dehydration and nutritional deficiencies: Lack of adequate fluids, iron, or other essential nutrients can lead to feelings of extreme tiredness.

Do Not Miss Diagnoses

  • Postpartum hemorrhage (late): Although less common, late postpartum hemorrhage can occur and may present with fatigue among other symptoms due to blood loss.
  • Pulmonary embolism: A life-threatening condition that can present with sudden onset of fatigue, among other symptoms like shortness of breath and chest pain.
  • Cardiomyopathy: Peripartum cardiomyopathy is a rare but potentially life-threatening condition that can cause fatigue, shortness of breath, and palpitations.
  • Infection (e.g., endometritis, mastitis): Can cause significant fatigue, along with fever, pain, and other localized symptoms.

Rare Diagnoses

  • Sheehan syndrome: A rare condition caused by necrosis of the pituitary gland, usually resulting from severe postpartum hemorrhage. It can lead to hypopituitarism, presenting with fatigue among other symptoms.
  • Adrenal insufficiency: Though rare, it can occur postpartum and cause fatigue, weight loss, and hypotension.
  • Mitochondrial myopathies: Rare genetic disorders affecting the mitochondria, which can cause extreme fatigue, among other symptoms.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.