From the Guidelines
Januvia (sitagliptin) is generally considered weight-neutral, meaning it typically does not cause significant weight gain in most patients. According to the most recent and highest quality study, 1, the weight effects of sitagliptin are listed as "Neutral", indicating that it does not have a significant impact on weight. This is consistent with other studies, such as 1, which also report a neutral or mild effect on weight gain. The standard dose of 100 mg once daily can be taken with or without food, and its mechanism of action works by increasing incretin levels, which inhibit glucagon release, thereby lowering blood glucose levels without stimulating insulin secretion in a glucose-independent manner. Unlike other diabetes medications, such as insulin, sulfonylureas, or thiazolidinediones, which often lead to weight gain as side effects, Januvia's mechanism of action doesn't promote fat storage or increased appetite. Some patients may even experience slight weight loss while taking sitagliptin, particularly when it's part of a comprehensive diabetes management plan that includes diet and exercise. However, individual responses can vary, and factors such as other medications, diet, physical activity, and overall diabetes management will influence weight outcomes while taking Januvia.
Key points to consider:
- Januvia is weight-neutral, with no significant impact on weight
- Its mechanism of action does not promote fat storage or increased appetite
- Individual responses may vary, and other factors can influence weight outcomes
- Comprehensive diabetes management, including diet and exercise, can help optimize weight outcomes while taking Januvia.
From the Research
Januvia and Weight Gain
- Januvia (sitagliptin) is a medication used to treat type 2 diabetes, and its effect on weight gain has been studied in several clinical trials 2, 3, 4, 5, 6.
- According to the studies, sitagliptin has a neutral effect on body weight, meaning it does not cause significant weight gain or loss 2, 3, 4, 5.
- In fact, one study found that sitagliptin was associated with a significant decrease in body weight and body mass index over a 12-week period 6.
- Another study found that sitagliptin had a low incidence of adverse events, including no weight gain, compared to other diabetes medications 2.
- The mechanism of sitagliptin's neutral effect on weight is not fully understood, but it may be related to its ability to suppress fasting serum ghrelin levels, a hormone that stimulates appetite 6.
Comparison to Other Diabetes Medications
- Sitagliptin has been compared to other diabetes medications, such as glipizide, and has been found to have a similar glucose-lowering effect without the risk of weight gain or hypoglycemia 3.
- In a 52-week clinical trial, sitagliptin was shown to be noninferior to glipizide as an add-on agent in patients inadequately controlled on metformin alone, with no significant difference in weight gain between the two groups 5.
Overall Findings
- The overall findings of the studies suggest that Januvia (sitagliptin) does not cause significant weight gain and may even be associated with weight loss in some patients 2, 3, 4, 5, 6.
- Sitagliptin's neutral effect on weight, combined with its ability to improve glycemic control and reduce the risk of hypoglycemia, make it a useful treatment option for patients with type 2 diabetes 2, 3, 4, 5, 6.