From the Guidelines
Anaemia is defined as a haemoglobin (Hb) concentration below the lower limit of normal for the relevant population and laboratory performing the test 1. The definition of anaemia can vary depending on the population and laboratory, but generally, it is considered as a haemoglobin concentration below 13 g/dl in men over 15 years of age, below 12 g/dl in non-pregnant women over 15 years of age, and below 11 g/dl in pregnant women 1. Some key points to consider when evaluating anaemia include:
- The lower limit of the normal range for the laboratory performing the test should be used to define anaemia 1
- Any level of anaemia should be investigated in the presence of iron deficiency 1
- Red cell indices provide a sensitive indication of iron deficiency in the absence of chronic disease or haemoglobinopathy 1
- Serum ferritin is the most powerful test for iron deficiency 1 It is essential to confirm iron deficiency by iron studies prior to investigation, and serum ferritin is the single most useful marker of iron deficiency anaemia (IDA) 1. Other blood tests, such as transferrin saturation, can be helpful if a false-normal ferritin is suspected 1. A good response to iron therapy, defined as a haemoglobin rise ≥10 g/L within a 2-week timeframe, is highly suggestive of absolute iron deficiency, even if the results of iron studies are equivocal 1. In the presence of biochemical evidence of inflammation, the lower limit of ferritin consistent with normal iron stores should be increased to 100 μg/L, and hypoferraemia should be considered likely if transferrin saturation is below 16% and serum ferritin is between 30 and 100 g/L 1. The determination of soluble transferrin receptor (sTfR) can help make a correct diagnosis, as it is high in iron deficiency and normal or low in anaemia of chronic disease (ACD) 1. It is crucial to evaluate the inflammatory status of the patient, as it can affect the interpretation of iron studies and the diagnosis of anaemia 1. In summary, the diagnosis of anaemia should be based on the lower limit of normal for the relevant population and laboratory, and iron deficiency should be confirmed by iron studies, including serum ferritin and transferrin saturation 1.
From the Research
Anemia Lab Results
There are no research papers to assist in answering this question, as the provided studies focus on acetaminophen toxicity, liver injury, and laboratory testing for acetaminophen concentrations, rather than anemia lab results.
- The studies provided do not mention anemia or its lab results 2, 3, 4, 5, 6
- The research papers discuss various topics such as false positive acetaminophen concentrations, evaluation and treatment of acetaminophen toxicity, and comparison of urine and serum testing for early detection of acetaminophen ingestion
- None of the studies provide information on anemia lab results or diagnosis 2, 3, 4, 5, 6