What is the prescription for Semaglutide (Rybelsus) 3mg (per oral) daily?

From the Guidelines

Semaglutide (Rybelsus) 3mg should be taken orally once daily, at least 30 minutes before intake of first food, fluid, or other oral medications of the day, with no more than 120 mL of plain water only, as recommended in the management guidelines for healthcare professionals 1. When writing a prescription for Rybelsus 3mg, it is essential to specify the dosage and administration instructions clearly to ensure the patient takes the medication correctly.

• The dosage is 3mg once daily.
• The route of administration is oral.
• The patient should take the medication at least 30 minutes before consuming any food, beverages, or other oral medications.
• The patient should take the medication with no more than 120 mL of plain water only. This timing and administration method are crucial because food and other substances can significantly reduce the absorption of the medication, potentially making it less effective 1. The medication works by mimicking the hormone GLP-1, which helps regulate blood sugar by increasing insulin secretion when blood sugar is high, decreasing glucagon secretion, slowing gastric emptying, and reducing appetite. Patients should store Rybelsus at room temperature and continue taking their other diabetes medications unless instructed otherwise by their healthcare provider. It is also important to note that Rybelsus 3mg is typically the starting dose for patients with type 2 diabetes to help minimize gastrointestinal side effects like nausea, vomiting, or diarrhea, and the dose may be increased after 30 days if needed for better glycemic control, as per the approved indications and recommended dosing for glycemic control 1.

From the Research

Prescription Details

To write a prescription for Semaglutide (Rybelsus) 3mg per oral daily, the following details should be considered:

• The medication name is Semaglutide, and it is marketed under the brand name Rybelsus 2.
• The prescribed dose is 3mg, which is one of the available doses for Rybelsus, including 3,7, and 14 mg 3.
• The route of administration is per oral (po), indicating that the medication should be taken by mouth.
• The frequency of administration is daily, meaning the patient should take the medication once every day.

Dosage and Administration

The dosage and administration of Rybelsus should be as follows:

• The initial dose may need to be escalated to reach the desired therapeutic effect, but the prescription specifies 3mg daily 3.
• Patients should be instructed to take the medication at the same time every day, preferably in the morning, to maintain a consistent drug concentration in the body.

Important Considerations

When prescribing Rybelsus, the following points are essential:

• Rybelsus is indicated for the treatment of type 2 diabetes as an adjunct to diet and exercise 4, 2.
• The medication has been shown to be effective in improving glycemic control and reducing body weight in patients with type 2 diabetes 4, 3, 5.
• Common adverse events associated with Rybelsus include gastrointestinal symptoms such as nausea and diarrhea 4, 3, 5.
• The safety profile of Rybelsus is consistent with the GLP-1 receptor agonist class, and cardiovascular safety has been demonstrated to be noninferior to placebo 4, 3.