From the FDA Drug Label
Food does not alter the bioavailability of lisinopril Lisinopril can be taken with or without food. The presence of food does not affect the bioavailability of the drug 1.
From the Research
Lisinopril can be taken either with or without food, as its absorption is not significantly affected by food intake. This ACE inhibitor medication used to treat high blood pressure and heart failure can be consumed at any time of day, regardless of meals. However, it's essential to take it at the same time each day to maintain consistent blood levels in your system. Some patients find taking lisinopril with food helps reduce stomach upset, though this side effect is uncommon. The key points to consider when taking lisinopril are:
- The medication can be taken with or without food, as food does not significantly affect its absorption 2
- It's crucial to take lisinopril at the same time each day to maintain consistent blood levels
- Some patients may experience dizziness when starting lisinopril, which is due to its blood pressure-lowering effect
- Lisinopril is effective in treating high blood pressure and heart failure, and its effectiveness remains consistent whether taken on an empty stomach or after eating 3, 4, 5, 6 If you experience any dizziness when starting lisinopril, this is because it lowers blood pressure by relaxing blood vessels, and your body may need time to adjust to this change. Remember to continue taking lisinopril even if you feel well, as hypertension often has no symptoms, and stopping the medication could lead to worsening of your condition.