From the FDA Drug Label
The FDA drug label does not answer the question.
From the Research
Bupropion XR 300mg is generally considered more effective than Bupropion SR 200mg due to its more consistent blood levels and once-daily dosing convenience, as supported by studies such as 1 which highlights the efficacy of bupropion XR in the treatment of seasonal affective disorder.
Key Considerations
- The XR formulation provides more consistent blood levels throughout the day with fewer peaks and troughs, which may result in fewer side effects for some patients 2, 3.
- Effectiveness ultimately depends on individual factors such as metabolism, specific condition being treated, and sensitivity to side effects.
- Some patients may respond better to the SR formulation despite its more frequent dosing schedule.
- The total daily dose also differs (300mg for XR vs. 400mg for SR if taken twice daily), which could impact both efficacy and side effects.
Formulation Comparison
- Bupropion SR 200mg is typically taken twice daily, while Bupropion XR 300mg is taken once daily.
- Both formulations are bioequivalent in terms of systemic exposure to bupropion, but the XR formulation may offer more consistent drug levels throughout the day 4.
- The choice between Bupropion SR and XR should be based on individual patient needs and preferences, as well as their specific medical history and treatment goals.
Clinical Evidence
- Studies such as 2, 3, and 1 provide evidence for the efficacy and safety of bupropion XR in the treatment of major depressive disorder and seasonal affective disorder.
- These studies suggest that bupropion XR is an effective and well-tolerated treatment option, with a convenient once-daily dosing schedule.