From the Guidelines
The diagnostic accuracy metrics for Coronary Artery Disease (CAD) using immunoprecipitation are not directly available, but based on the most recent and highest quality study, coronary computed tomography angiography (CCTA) has a reported high accuracy for detecting CAD, with a sensitivity of 95% and a specificity of 83% 1. The study found that CCTA possesses high diagnostic accuracy for detecting coronary stenosis at thresholds of 50% 1.
- The diagnostic performance of CCTA was not influenced by angina pectoris type 1.
- The CORE-64 study reported a receiver operating characteristic (ROC) area for cardiac CT of 0.93 using quantitative coronary angiography as the reference standard 1.
- A meta-analysis to evaluate the diagnostic accuracy of 64-slice CCTA compared with conventional selective coronary angiography in symptomatic patients with suspected CAD included 27 studies and 1,740 patients and found that the sensitivity, specificity, PPV, and NPV were 86%, 96%, 83%, and 96.5%, respectively, by per-segment analysis and 97.5%, 91%, 93%, and 96.5%, respectively, by per-patient analysis 1. However, it is essential to note that the provided evidence does not directly address the diagnostic accuracy metrics for CAD using immunoprecipitation, and therefore, the recommendation is based on the available data for CCTA, which is a different diagnostic method. In clinical practice, this implies that a positive result from a diagnostic test like CCTA strongly confirms CAD, but a negative result doesn't necessarily rule it out, and additional testing methods should be considered for patients with negative results who still show clinical signs of CAD. The high specificity of diagnostic tests like CCTA makes them particularly valuable for confirming diagnosis rather than as a screening tool. It is crucial to consider the clinical likelihood of CAD and other patient characteristics that influence test performance, local expertise, and the availability of tests when selecting the initial non-invasive diagnostic test 1.
From the Research
Diagnostic Accuracy Metrics for Coronary Artery Disease (CAD) using Immunoprecipitation
There are no research papers to assist in answering this question as the provided studies do not discuss the diagnostic accuracy metrics for Coronary Artery Disease (CAD) using immunoprecipitation. The studies provided focus on the use of immunoprecipitation to detect autoantibodies in patients with dermatomyositis and interstitial lung disease, but do not mention CAD.
Available Data on Immunoprecipitation
- The studies provided discuss the use of immunoprecipitation to detect autoantibodies such as anti-TIF1-gamma, anti-CADM-140, and anti-MDA5 in patients with dermatomyositis and interstitial lung disease 2, 3, 4, 5, 6.
- The sensitivity and specificity of immunoprecipitation for detecting these autoantibodies are reported in some of the studies, but not in the context of CAD diagnosis 2, 4, 5, 6.
- The studies suggest that immunoprecipitation can be a useful tool for detecting autoantibodies in patients with dermatomyositis and interstitial lung disease, but its application in CAD diagnosis is not explored 2, 3, 4, 5, 6.