From the Guidelines
Perenterol is the preferred choice for digestive enzyme supplementation in patients with pancreatic insufficiency, as it contains pancreatin, which is specifically targeted for this condition. The decision between Ab digest and Perenterol depends on the specific digestive issue being addressed. Ab digest, containing a blend of digestive enzymes, is generally preferred for comprehensive digestive support as it contains multiple enzymes that help break down proteins, carbohydrates, and fats. The typical dosage is 1-2 capsules with meals 1. Perenterol, which contains pancreatin (a mixture of pancreatic enzymes including amylase, lipase, and protease), is more specifically targeted for pancreatic insufficiency conditions, such as chronic pancreatitis, and the standard dosage is typically 1-2 capsules before or during meals 1.
For general digestive discomfort or occasional indigestion, Ab digest may be more appropriate, while Perenterol might be better suited for those with diagnosed pancreatic enzyme deficiencies or conditions like chronic pancreatitis. Both supplements work by replacing or supplementing the natural enzymes that the body may not be producing in sufficient quantities, thereby improving the breakdown of food and absorption of nutrients. According to the AGA clinical practice update on the epidemiology, evaluation, and management of exocrine pancreatic insufficiency, the use of PERT in patients with CP and EPI improves outcomes 1.
Key points to consider when choosing between Ab digest and Perenterol include:
- The specific digestive issue being addressed
- The presence of pancreatic insufficiency or other conditions that may require targeted enzyme supplementation
- The dosage and efficacy of the supplement, with Perenterol typically requiring a dosage of at least 40,000 USP units of lipase during each meal in adults 1
- The importance of monitoring fat-soluble vitamin levels and making dietary modifications to support digestive health 1.
It's essential to note that persistent digestive issues should be evaluated by a healthcare provider before starting any enzyme supplement regimen to ensure proper diagnosis and treatment. Additionally, over-the-counter commercially available pancreas enzyme replacements should not be used, as they are classified as dietary supplements only and their dosing and efficacy are neither standardized nor regulated 1.
From the Research
Comparison of Ab Digest and Perenterol
- Ab Digest is a digestive enzyme supplement, while Perenterol is a type of pancreatin, which is an extract of pancreatic enzymes 2.
- The choice between Ab Digest and Perenterol depends on the specific needs of the individual, as Perenterol is typically used to treat exocrine pancreatic insufficiency, while Ab Digest may be used for general digestive support [(2,3)].
Mechanism of Action
- Perenterol, being a pancreatin, works by replacing the missing pancreatic enzymes in individuals with exocrine pancreatic insufficiency, thereby helping to digest food and absorb nutrients [(2,4)].
- Ab Digest, on the other hand, is a broad-spectrum digestive enzyme supplement that may help support digestion, but its mechanism of action is not as specific to pancreatic insufficiency as Perenterol [(5,6)].
Efficacy and Safety
- Studies have shown that Perenterol can be effective in reducing steatorrhea and improving nutritional status in individuals with exocrine pancreatic insufficiency [(4,5)].
- The safety and efficacy of Ab Digest have not been extensively studied in the context of pancreatic insufficiency, but it may be a useful supplement for general digestive support [(6,3)].
Dosage and Administration
- The dosage of Perenterol typically ranges from 20,000 to 40,000 units of lipase per meal, with adjustments made as needed 2.
- The dosage and administration of Ab Digest may vary depending on the specific product and individual needs, but it is generally recommended to follow the manufacturer's instructions [(6,3)].