From the Research
The most effective treatment for angular cheilitis is the application of 1% isoconazole nitrate (ISN) and 0.1% diflucortolone valerate (DFV) ointment, due to its broad spectrum of activity against dermatophytes and bacteria, and its anti-inflammatory properties 1. This approach is supported by a recent narrative review and clinical experience, which highlights the importance of addressing both the underlying causes and symptoms of angular cheilitis. Some key points to consider in the treatment of angular cheilitis include:
- Keeping the affected area clean and dry
- Applying an antifungal cream or ointment, such as 1% isoconazole nitrate (ISN) and 0.1% diflucortolone valerate (DFV), to the corners of the mouth 2-3 times daily for 1-2 weeks
- Avoiding licking the corners of the mouth and applying petroleum jelly as a barrier
- Staying hydrated and addressing underlying factors, such as nutritional deficiencies (particularly B vitamins, iron, and zinc), to prevent recurrence
- Managing conditions like diabetes and avoiding irritants It's also important to note that if symptoms persist beyond 2-3 weeks despite treatment, or if they're severe or recurrent, medical evaluation is necessary to identify potential systemic conditions contributing to the problem 2, 3. Additionally, correcting ill-fitting dentures and treating cutaneous diseases can also help in preventing the recurrence of angular cheilitis 4, 5. Overall, a comprehensive approach that addresses both the local and systemic factors contributing to angular cheilitis is essential for effective treatment and prevention of recurrence.