There are no official guidelines to assist in answering this question. I will search for relevant research papers instead.
From the Research
Overview of the McCullough Protocol
There is limited scientific evidence available to support the McCullough protocol.
Available Evidence
- The study by 1 proposes a base spike detoxification protocol, composed of oral nattokinase, bromelain, and curcumin, which may be beneficial in aiding the resolution of post-acute sequelae after SARS-CoV-2 infection and COVID-19 vaccination.
- However, this study does not provide direct evidence for the McCullough protocol, and large-scale, prospective, randomized, double-blind, placebo-controlled trials are warranted to determine the relative risks and benefits of the base spike detoxification protocol.
- Other studies, such as 2, 3, 4, and 5, do not provide relevant evidence for the McCullough protocol, as they focus on different topics, including COVID-19 diagnosis and management, clinical approach to post-acute sequelae, methodological guidance for mixed methods systematic reviews, and surgical interventions for plantar fasciopathy.
Gaps in Evidence
- There is a lack of research papers that directly investigate the McCullough protocol, making it challenging to provide a comprehensive evaluation of its effectiveness and safety.
- Further studies are needed to fill this knowledge gap and provide evidence-based recommendations for the use of the McCullough protocol.