From the Guidelines
It is not recommended to take two 150mg bupropion (Wellbutrin) XL tablets at once to make a 300mg dose unless specifically directed by your healthcare provider. Bupropion XL is designed to release medication at specific rates, and taking multiple lower-dose tablets could alter this release profile 1. The standard dosing information for bupropion indicates that the maximum daily dose is 300mg, and this should be achieved by taking a single 300mg tablet or 150mg tablets twice daily, if tolerated 1. Some key points to consider when taking bupropion include:
- The medication is contraindicated for patients with seizure risks, such as those with a history of stroke or brain metastases 1
- Bupropion can increase the risk of serious neuropsychiatric issues, including depression and suicidal ideation/behavior, and patients should be monitored for these side effects 1
- Dose adjustments should always be made under medical supervision due to the risks associated with this medication, including seizures, especially when doses are changed 1 If your doctor wants to increase your dose to 300mg, they should prescribe the appropriate 300mg tablets to ensure safe and effective treatment. It's essential to consult with your healthcare provider before making any changes to your medication regimen.
From the Research
Bupropion XL Dosage
- The recommended dosage of bupropion XL is once daily, with a maximum daily dose of 300mg 2.
- Taking two 150mg bupropion XL tablets at the same time would result in a total dose of 300mg, which is within the recommended maximum daily dose.
- However, it is essential to note that taking extra doses of bupropion can increase the risk of adverse effects, including seizures, agitation, dizziness, and nausea 3.
Pharmacokinetics and Formulations
- Bupropion XL has a prolonged absorption compared to the immediate release (IR) and sustained release (SR) formulations, with a T(max) of approximately 5 hours 4.
- The three formulations of bupropion (IR, SR, and XL) are bioequivalent and offer options to optimize treatment for patients with major depressive disorder 4, 5.
- Bupropion is extensively metabolized by the liver, resulting in three active metabolites, and its pharmacokinetic profile should be considered when prescribing the medication 4, 6.
Safety and Efficacy
- Bupropion is generally well tolerated, with common adverse events including insomnia, headache, dry mouth, nausea, and anxiety 2.
- The medication is effective in the treatment of major depressive disorder, with the XL formulation demonstrating efficacy in terms of primary and secondary outcomes 5.
- However, patients should be educated about the risks associated with extra doses of bupropion, and the medication should be used with caution in patients with predisposing risk factors for seizure 2, 3.