From the Research
Vyvanse (lisdexamfetamine) can potentially cause canker sores in some individuals due to its side effects, such as dry mouth and appetite suppression, which can lead to vitamin deficiencies and increased risk of oral tissue injuries. The medication's official documentation does not list canker sores as a common side effect, but indirect mechanisms may contribute to their development. Dry mouth (xerostomia) caused by Vyvanse can create an environment where oral tissues are more vulnerable to minor injuries that can develop into canker sores. Additionally, Vyvanse may lead to decreased nutritional intake due to appetite suppression, potentially causing vitamin deficiencies (particularly B vitamins and zinc) that are associated with canker sore development, as suggested by a study on the role of vitamin B12 in treating recurrent aphthous stomatitis 1. Some users also report increased teeth grinding or jaw clenching (bruxism) while taking stimulant medications, which can create small injuries to the mouth's soft tissues.
To manage canker sores while taking Vyvanse, it is essential to:
- Stay well-hydrated to combat dry mouth
- Maintain good oral hygiene
- Use alcohol-free mouthwash
- Ensure adequate nutrition, potentially including vitamin B12 supplements, as a study suggests that a daily dose of 1000 μg of vitamin B12 sublingually for six months can be used to treat recurrent aphthous stomatitis 1
- Possibly use over-the-counter canker sore treatments, such as mucoadhesive tablets that release natural active agents for pain reduction and rapid healing of canker sores 2
If the sores are severe, persistent, or significantly interfering with eating or speaking, it is crucial to consult a healthcare provider, as they might suggest adjusting the medication dosage or recommending specific treatments for the canker sores. The pharmacological properties and clinical effects of Vyvanse have been studied, and while it is effective in treating attention-deficit/hyperactivity disorder (ADHD), its potential to cause canker sores should be considered in the context of overall patient health and quality of life 3.