From the FDA Drug Label
Cefazolin for Injection, USP is a semi-synthetic cephalosporin for parenteral administration. The type of antibiotic (abx) Ancef (Cefazolin) is is a cephalosporin, specifically a semi-synthetic cephalosporin 1.
From the Research
Ancef (Cefazolin) is a first-generation cephalosporin antibiotic. It is primarily effective against gram-positive bacteria, including Staphylococcus aureus (including methicillin-sensitive strains), Streptococcus species, and some gram-negative organisms. Cefazolin works by inhibiting bacterial cell wall synthesis by binding to penicillin-binding proteins, which leads to cell lysis and death.
Key Points
- It is commonly used for surgical prophylaxis, skin and soft tissue infections, and certain respiratory and urinary tract infections.
- The typical adult dose ranges from 1-2 grams every 8 hours intravenously, with adjustments needed for renal impairment.
- Cefazolin has a relatively narrow spectrum compared to later-generation cephalosporins, which helps limit antimicrobial resistance and collateral damage to the normal flora.
- It generally has good tissue penetration and a favorable safety profile, though patients with penicillin allergies should be assessed for potential cross-reactivity before administration, as noted in a study published in 2.
Clinical Use
Some of the key considerations for the use of Ancef include:
- Its effectiveness against a range of gram-positive and some gram-negative bacteria.
- The need for careful assessment of patients with penicillin allergies due to potential cross-reactivity.
- The importance of appropriate dosing and adjustment for renal impairment to ensure efficacy and minimize toxicity. As supported by the most recent and highest quality study available 2, Cefazolin is a safe and effective choice for surgical prophylaxis and the treatment of certain infections, particularly when considering its narrow spectrum of activity and favorable safety profile.