From the FDA Drug Label
Signs and symptoms reported in the literature after caffeine overdose in preterm infants include ... fine tremor of the extremities, hypertonia, opisthotonos, tonic-clonic movements, The FDA drug label does not answer the question.
From the Research
Yes, 800mg of caffeine can cause muscle twitching, as it exceeds the recommended daily limit and can lead to overstimulation of the nervous system. This is supported by the most recent and highest quality study available, which found that caffeine intake can significantly improve voluntary activation, potentiated twitch, and M-wave, indicating its effects on neuromuscular fatigue 1. At high levels, caffeine can block adenosine receptors and increase the release of neurotransmitters like dopamine and norepinephrine, leading to hyperexcitability in muscles and nerves. Other symptoms that may occur with excessive caffeine consumption include rapid heartbeat, anxiety, insomnia, digestive issues, and in severe cases, heart palpitations or irregular heartbeat.
Some key points to consider:
- Caffeine consumption above 400mg daily can lead to adverse effects, including muscle twitching, as noted in studies from 2012 and 1987 2, 3.
- The effects of caffeine on the body are influenced by individual metabolism, which can be affected by various factors, including age, health status, and other substances consumed 2.
- High doses of caffeine, such as 800mg, can cause significant cardiovascular and central nervous system toxicity, as reported in a case study from 2021 4.
- Reducing caffeine intake immediately and allowing the body time to metabolize the caffeine can help mitigate symptoms, with hydration also playing a role in symptom management.
Overall, it is crucial to keep caffeine consumption below 400mg daily to minimize the risk of adverse effects, including muscle twitching. If muscle twitching occurs after consuming high amounts of caffeine, it is essential to reduce intake and allow the body to process the caffeine, typically taking 4-6 hours for half of it to be metabolized. Staying hydrated can help alleviate some symptoms, but the best approach is to maintain caffeine consumption within the recommended daily limit.