Differential Diagnosis for Facial Flushing
Single Most Likely Diagnosis
- Benign Cutaneous Flush: This is the most common cause of facial flushing, often triggered by emotional responses, spicy food, alcohol, or temperature changes. It's usually harmless and resolves on its own.
Other Likely Diagnoses
- Menopause: Hormonal changes during menopause can lead to hot flashes, which often manifest as facial flushing.
- Anxiety or Panic Attacks: Stress and anxiety can cause blood vessels to dilate, leading to flushing of the face.
- Carcinoid Syndrome: Although less common, this condition, often associated with neuroendocrine tumors, can cause flushing due to the release of serotonin and other substances.
- Medication Side Effects: Certain medications, such as niacin, tamoxifen, and some antidepressants, can cause facial flushing as a side effect.
Do Not Miss Diagnoses
- Pheochromocytoma: A rare tumor of the adrenal gland that can cause episodic flushing, hypertension, and other symptoms. Missing this diagnosis could be life-threatening due to the risk of hypertensive crises.
- Thyroid Storm: A life-threatening complication of untreated or undertreated hyperthyroidism, which can present with flushing, among other symptoms.
- Mastocytosis: A condition characterized by the accumulation of mast cells in the skin and other organs, which can cause flushing, especially after certain triggers.
Rare Diagnoses
- Erythromelalgia: A disorder that causes burning pain, heat, and redness in the hands and feet, and sometimes the face.
- Harlequin Syndrome: A rare condition characterized by asymmetric flushing and sweating of the face, often triggered by emotional stress or exercise.
- Autonomic Dysfunction: Certain conditions affecting the autonomic nervous system, such as multiple system atrophy, can lead to abnormal blood vessel regulation and facial flushing.