From the Guidelines
The best time to take Hyzaar (losartan/hydrochlorothiazide) is at the most convenient time of day to improve adherence, as current evidence does not show a benefit of diurnal timing of BP-lowering drug administration on major CVD outcomes 1. Taking this medication at the same time each day helps maintain consistent blood levels for better blood pressure control throughout the day. Some key points to consider when taking Hyzaar include:
- Taking it consistently with respect to food - either always with food or always without food - to help maintain predictable absorption.
- If you experience any dizziness when standing up after taking Hyzaar, you might consider taking it in the evening instead.
- The hydrochlorothiazide component is a diuretic that increases urination, so taking it in the morning helps avoid nighttime bathroom trips that could disrupt sleep.
- If you miss a dose, take it as soon as you remember, but skip it if it's almost time for your next dose rather than doubling up. Hyzaar works by combining losartan (which blocks angiotensin II receptors, relaxing blood vessels) with hydrochlorothiazide (which removes excess fluid from the body), providing complementary mechanisms to lower blood pressure effectively, as recommended by recent guidelines for the management of elevated blood pressure and hypertension 1.
From the Research
Administration Time of Hyzaar
The optimal time to take Hyzaar (Losartan/Hydrochlorothiazide) is not explicitly stated in the provided studies. However, the studies suggest that Hyzaar can be taken once daily, and its antihypertensive effects can last for 24 hours.
Key Findings
- A study published in 1996 found that the concomitant administration of losartan potassium and hydrochlorothiazide once daily produced an additive reduction in trough sitting systolic and diastolic blood pressure and was well tolerated 2.
- Another study published in 1998 compared the antihypertensive efficacy of losartan and amlodipine and found that losartan alone reduced both office and ambulatory blood pressure readings, but its full antihypertensive efficacy may be delayed for up to 12 weeks 3.
- A study published in 2001 found that losartan/hydrochlorothiazide was effective and well tolerated in the treatment of patients with severe hypertension, with most patients achieving blood pressure control after 12 weeks of treatment 4.
- Other studies have also shown that losartan/hydrochlorothiazide is effective and well tolerated in the treatment of patients with mild to moderate essential hypertension, and that it can be taken once daily 5, 6.
Dosage and Administration
- The typical dosage of Hyzaar is 50/12.5 mg once daily, with the option to increase the dose to 100/25 mg if necessary.
- The studies suggest that Hyzaar can be taken in the morning, as its antihypertensive effects can last for 24 hours.
- However, the optimal time to take Hyzaar may vary depending on individual patient factors, such as lifestyle and other medications.