What is the maximum daily dose of Methazolamide (Carbonic Anhydrase Inhibitor)?

There are no official guidelines to assist in answering this question. I will search for relevant research papers instead.

From the FDA Drug Label

Methazolamide 25 mg bid, 50 mg bid, and 100 mg bid demonstrated a linear relationship between plasma methazolamide levels and methazolamide dose. The maximum daily dose of Methazolamide is not explicitly stated in the provided drug label.

From the Research

Maximum Daily Dose of Methazolamide

The maximum daily dose of Methazolamide can be determined from the following studies:

• A study published in 1978 1 found that patients with open-angle glaucoma were given weekly courses of methazolamide at different dosages, with a mean reduction in outflow pressure for all eyes receiving a daily dosage of 300 mg.
• A study published in 2024 2 evaluated the safety and efficacy of sublingual methazolamide in patients with open-angle glaucoma, with participants receiving either 25 mg or 50 mg of sublingual methazolamide once daily for one week, followed by twice-daily administration during the second week.

Key Findings

• The studies suggest that the maximum daily dose of Methazolamide is around 300 mg, divided into three doses of 100 mg every eight hours 1.
• However, the 2024 study 2 used a lower dose of 25 mg or 50 mg once daily, with twice-daily administration during the second week, and still achieved significant reductions in intraocular pressure.
• Another study published in 2011 3 used a dose of 25 mg twice daily to treat ankylosing spondylitis, with positive results.

Dosage Information

• The following dosages have been used in studies:
  • 25 mg every eight hours 1
  • 50 mg every eight hours 1
  • 100 mg every eight hours 1
  • 25 mg twice daily 3
  • 25 mg or 50 mg once daily, with twice-daily administration during the second week 2
  • 300 mg daily, divided into three doses 1