From the Research
Ademetionine 400mg tablets are primarily used to treat liver disorders and depression, with the typical dosage ranging from 400-800mg daily for liver conditions and 400-1600mg daily for depression. The medication works as a methyl donor in various biochemical reactions in the body, helping to maintain cell membranes and produce important compounds like glutathione that protect the liver 1.
Key Considerations
- For liver conditions such as chronic hepatitis and cirrhosis, the medication should be taken on an empty stomach.
- When used for depression, doses may be divided into multiple doses.
- Patients should take the tablets whole without crushing them and store them in a cool, dry place as the compound is sensitive to heat and moisture.
- Side effects may include nausea, digestive discomfort, anxiety, insomnia, and headaches.
Important Warnings
- Ademetionine should not be used by patients taking certain antidepressants, particularly MAOIs.
- Those with bipolar disorder should use it only under close medical supervision as it may trigger manic episodes.
- Always consult with a healthcare provider before starting this medication, especially considering the potential for medication errors and adverse drug events as highlighted in recent studies 2.
Dosage and Administration
- The dosage and administration of Ademetionine 400mg tablets should be carefully managed to minimize the risk of medication errors, which can be significant in patients with mental illness 2.
- Healthcare professionals should be aware of the potential for prescribing faults, including irrational, inappropriate, and ineffective prescribing, underprescribing, and overprescribing 1.
Patient Education
- Patients should be educated on the proper use of Ademetionine 400mg tablets, including the importance of taking the medication as directed and reporting any side effects or concerns to their healthcare provider.
- Patients should also be aware of the potential interactions with other medications, including antidepressants, and the need for close medical supervision in certain cases.