From the Guidelines
The recommended treatment regimen for Gastroesophageal Reflux Disease (GERD) using Dexilant (dexlansoprazole) typically involves a 30 mg capsule taken once daily for 4 to 8 weeks, as supported by recent clinical guidelines 1. For patients with moderate to severe GERD or erosive esophagitis, a higher dose of 60 mg once daily may be prescribed initially. Dexilant should be taken regardless of meals, as it is effective independent of food intake. Some key points to consider in the treatment of GERD with Dexilant include:
- Initial treatment with a 30 mg capsule once daily for 4 to 8 weeks
- Potential escalation to 60 mg once daily for moderate to severe cases
- Maintenance therapy with 30 mg daily for up to 6 months
- Importance of lifestyle modifications, such as avoiding trigger foods, eating smaller meals, and maintaining a healthy weight
- Potential need for dosage adjustments or additional evaluation if symptoms persist despite treatment, as persistent GERD can lead to complications like Barrett's esophagus or esophageal strictures, as noted in various studies 1. It's also important to consider the role of upper endoscopy in the management of GERD, particularly in patients with alarm symptoms or those who do not respond to initial treatment, as discussed in the guidelines 1.
From the FDA Drug Label
1.3 Treatment of Symptomatic Non-Erosive Gastroesophageal Reflux Disease Dexlansoprazole delayed-release capsules are indicated in patients 12 years of age and older for the treatment of heartburn associated with symptomatic non-erosive gastroesophageal reflux disease (GERD) for four weeks.
2.1 Recommended Dosage in Patients 12 Years of Age and Older Table 1: Recommended Dexlansoprazole Delayed-Release Capsules Dosage Regimen by Indication in Patients 12 Years of Age and Older Indication Dosage of Dexlansoprazole Capsules Duration ... Symptomatic Non-Erosive GERD One 30 mg capsule once daily. 4 weeks.
The recommended treatment regimen for Gastroesophageal Reflux Disease (GERD) using Dexilant (Dexlansoprazole) is:
- Dosage: One 30 mg capsule once daily
- Duration: 4 weeks 2
From the Research
Treatment Regimen for Gastroesophageal Reflux Disease (GERD) using Dexilant (Dexlansoprazole)
- The recommended treatment regimen for GERD using Dexilant (Dexlansoprazole) involves a daily dose of 30 or 60 mg, depending on the severity of the disease 3, 4.
- Dexlansoprazole modified release (MR) can be dosed without regard to food intake or time of day, and once-daily dosing may replace twice-daily dosing of other agents 3.
- Studies have shown that dexlansoprazole MR is effective for healing and maintenance of erosive esophagitis, and for the treatment of nonerosive disease, including nocturnal gastroesophageal reflux disease 3, 4.
Efficacy of Dexlansoprazole in GERD Treatment
- Dexlansoprazole has been shown to be effective in improving the healing of all grades of erosive oesophagitis, maintaining the healing of erosive oesophagitis, and in the treatment of symptomatic non-erosive reflux disease (NERD) 4.
- A study comparing the clinical efficacy of dexlansoprazole and esomeprazole found that the symptom relief effect for GERD after 24 weeks was similar for both treatments, but dexlansoprazole exhibited fewer days with reflux symptoms in the 24-week study period 5.
- Another study found that dexlansoprazole had a significantly higher response rate than lansoprazole in patients with atypical symptoms of GERD, including cough and globus 6.
Safety and Tolerability of Dexlansoprazole
- Dexlansoprazole MR has been shown to be safe and well tolerated in patients with GERD, with a low incidence of adverse events 3, 7.
- A study in adolescent patients with symptomatic GERD found that dexlansoprazole MR was well tolerated, with all adverse events being of mild severity 7.
- The pharmacokinetic profile of dexlansoprazole in adolescent patients was similar to that in healthy adults, with no significant differences in exposure or safety 7.