From the Guidelines
The recommended dosage of Nurtec ODT (rimegepant) for acute migraine treatment is 75 mg taken orally as a single dose as needed, with a maximum frequency of once every 24 hours. This is based on the most recent and highest quality study available, which suggests that CGRP antagonists like rimegepant are effective for treating moderate to severe acute episodic migraine headache in nonpregnant outpatient adults who do not tolerate or have inadequate response to combination therapy of a triptan and an NSAID or acetaminophen 1.
Key Considerations
- Nurtec ODT is a dissolvable tablet that should be placed on or under the tongue, and patients should avoid eating or drinking for 10 minutes after taking the medication to ensure proper absorption.
- Patients should take Nurtec at the first sign of a migraine for best results, rather than waiting until the pain becomes severe.
- Unlike some other migraine medications, Nurtec has no cardiovascular restrictions and can be used in patients with heart disease or risk factors for cardiovascular disease.
- It is essential to counsel patients on the potential risks of medication overuse headache and the importance of not exceeding the recommended dosage or frequency of use 1.
Additional Guidance
- Consider treating mild episodic migraine headache with an NSAID, acetaminophen, or the combination of an NSAID and acetaminophen.
- For patients who do not respond to initial treatment, consider adding a triptan or using a nonoral triptan and an antiemetic in people having severe nausea or vomiting.
- Patients should be aware of the potential complications of migraine treatment, including medication overuse headache, and the importance of discussing the risks and benefits of pharmacologic treatments during pregnancy and lactation.
From the FDA Drug Label
2.1 Recommended Dosing for Acute Treatment of Migraine The recommended dose of NURTEC ODT is 75 mg taken orally, as needed. The maximum dose in a 24-hour period is 75 mg.
The recommended dosage of Nurtec ODT (rimegepant) for acute migraine treatment is 75 mg taken orally, as needed, with a maximum dose of 75 mg in a 24-hour period 2.
- The safety of using more than 18 doses in a 30-day period has not been established.
From the Research
Dosage Information for Nurtec ODT (Rimegepant)
- The recommended dosage of Nurtec ODT (rimegepant) for acute migraine treatment is 75 mg, as indicated in studies 3, 4, 5, 6, 7.
Efficacy of Rimegepant
- Rimegepant has shown efficacy in treating acute migraine attacks, with significant reductions in headache intensity and freedom from the most bothersome symptoms at 2 hours post-dose 3, 4, 5, 6, 7.
Safety and Tolerability
- Rimegepant has been found to be safe and well-tolerated, with mild adverse events reported in some studies 3, 4, 5, 6, 7.