What is the recommended dosing for Ubrelvy (Ubrogepant) 100mg for acute migraine treatment?

From the Guidelines

The recommended dosing for Ubrelvy (ubrogepant) 100mg for acute migraine treatment is one 100mg tablet taken orally at the onset of migraine pain, with or without food, as supported by the most recent clinical guideline from the American College of Physicians 1.

Key Considerations

• If needed, a second 100mg dose may be taken at least 2 hours after the initial dose.
• The maximum daily dosage should not exceed 200mg (two 100mg tablets) within a 24-hour period.
• Patients should wait at least 24 hours before treating another migraine attack with Ubrelvy.

Mechanism and Usage

This medication works by blocking calcitonin gene-related peptide (CGRP) receptors, which play a key role in migraine development. Ubrelvy should be used only for acute treatment of migraine attacks and not for preventive therapy.

Special Populations and Side Effects

Patients with severe renal or hepatic impairment may require dose adjustments. Common side effects include nausea, tiredness, and dry mouth. Patients should inform their healthcare provider about all medications they are taking, as certain drugs (particularly strong CYP3A4 inhibitors) may interact with Ubrelvy and require dosage adjustments, as noted in the clinical guideline 1.

Clinical Context

The American College of Physicians guideline suggests considering CGRP antagonists like ubrogepant for moderate to severe acute episodic migraine headache in nonpregnant outpatient adults who do not tolerate or have inadequate response to combination therapy of a triptan and an NSAID or acetaminophen 1.

From the FDA Drug Label

The recommended dose of UBRELVY is 50 mg or 100 mg taken orally with or without food. If needed, a second dose may be taken at least 2 hours after the initial dose. The maximum dose in a 24-hour period is 200 mg. The recommended dosing for Ubrelvy (Ubrogepant) 100mg for acute migraine treatment is 100 mg taken orally with or without food.

• A second dose of 100 mg may be taken at least 2 hours after the initial dose if needed.
• The maximum dose in a 24-hour period is 200 mg. 2

From the Research

Ubrelvy 100mg Dosing for Acute Migraine Treatment

• The recommended dosing for Ubrelvy (Ubrogepant) 100mg for acute migraine treatment is as follows:
  • Ubrogepant can be administered as 50- and 100-mg tablets, with a maximum dose of 200 mg within 48 hours 3
  • The 100mg dose of ubrogepant was shown to be effective in achieving freedom from pain and absence of the most bothersome migraine-associated symptom at 2 hours after the dose 4
• Efficacy and Safety:
  • Ubrogepant 100mg was effective in alleviating migraine-associated symptoms such as nausea, photophobia, and sound sensitivity 3
  • The most common adverse events reported with ubrogepant 100mg were nausea, somnolence, and dry mouth 4
• Patient-Reported Outcomes:
  • Ubrogepant 100mg improved patient-reported functional disability and satisfaction in two single-attack phase 3 randomized trials, ACHIEVE I and II 5
  • A significantly higher proportion of participants treated with ubrogepant 100mg reported being able to function normally, were satisfied with the study medication, and reported clinically meaningful improvement compared with those receiving placebo 5
• Concomitant Use with Other Medications:
  • The safety and tolerability of ubrogepant 100mg for the acute treatment of migraine in participants taking atogepant for the preventive treatment of episodic migraine were evaluated in the TANDEM study 6
  • The use of atogepant 60mg QD for the preventive treatment of episodic migraine and ubrogepant 100mg PRN for the acute treatment of migraine over the 12-week open-label concomitant use treatment period was safe and well tolerated 6