Can I use Robaxin (Methocarbamol) if I am allergic to Flexeril (Cyclobenzaprine)?

From the Research

If you are allergic to Flexeril (cyclobenzaprine), you should consult with your healthcare provider before taking Robaxin (methocarbamol) due to the potential for cross-reactivity and significant side effects. While these medications are different muscle relaxants with distinct chemical structures, there is a small possibility of cross-reactivity between them [ 1 ]. Robaxin works by depressing the central nervous system to relieve muscle spasms, while Flexeril is a centrally acting muscle relaxant that works by blocking nerve impulses.

Key Considerations

• Your healthcare provider needs to evaluate your specific allergy symptoms to Flexeril, review your complete medical history, and determine if Robaxin would be safe for you [ 2 ].
• They might recommend starting with a lower dose of Robaxin to monitor for any allergic reactions if they deem it appropriate.
• Never self-prescribe muscle relaxants, as they can have significant side effects including drowsiness, dizziness, and potential interactions with other medications you may be taking [ 3 ].

Evidence-Based Recommendation

The most recent and highest quality study [ 2 ] suggests that the choice of a skeletal muscle relaxant should be based on its adverse-effect profile, tolerability, and cost. Given the potential for cross-reactivity and significant side effects, it is essential to consult with a healthcare provider before taking Robaxin if you are allergic to Flexeril.

Potential Side Effects

• Dizziness and drowsiness are consistently reported with all skeletal muscle relaxants [ 2 ].
• Methocarbamol and metaxalone are less sedating, although effectiveness evidence is limited [ 2 ].
• The potential adverse effects should be communicated clearly to the patient [ 2 ].