From the Research
Latuda (lurasidone) dosage can be increased by 20mg increments, which is the standard titration approach recommended by prescribers. Typically, patients start at 40mg once daily, and if needed, the dose can be increased to 60mg, then 80mg, and potentially up to the maximum dose of 120mg daily (for schizophrenia) or 80mg daily (for bipolar depression) 1. While 10mg increments are not standard practice, some psychiatrists might occasionally use smaller adjustments for patients who are particularly sensitive to medication changes or experiencing side effects. Latuda should be taken with at least 350 calories of food to maximize absorption, as taking it without food significantly reduces its effectiveness. Dose adjustments should always be made under medical supervision, as changes can affect both therapeutic response and side effects such as akathisia (restlessness), nausea, or somnolence 2, 3. Patients with renal or hepatic impairment typically require lower doses, and adjustments should be made more cautiously in these populations.
It's worth noting that the most recent and highest quality study 4 suggests that lurasidone is as effective as other atypical agents, with a lower propensity for metabolic side effects and a relatively benign neurocognitive side effect profile. However, this study does not specifically address the dosage increment, but it supports the overall safety and efficacy of lurasidone.
In terms of dosage adjustment, it's crucial to consider the patient's individual response to the medication and potential side effects. As stated in the study 5, patients switching to lurasidone from another antipsychotic may experience weight reduction and/or improvements in the ability to focus/concentrate, but they may also experience somnolence, akathisia, nausea, or parkinsonism, especially early in treatment.
Overall, when adjusting the dosage of Latuda, it's essential to prioritize the patient's safety and well-being, and to make adjustments under medical supervision to minimize potential side effects and optimize therapeutic response.