What are the effective supplements for burning fat?

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Last updated: June 25, 2025View editorial policy

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From the Guidelines

There is no clear evidence that nutrition supplements are effective for weight loss or burning fat, and they are not recommended. According to the most recent and highest quality study, 1, nutrition supplements have not been shown to be effective for weight loss and are not recommended. The study emphasizes that reducing processed and ultraprocessed food intake is a more encouraging area of ongoing weight loss research.

Some key points to consider:

  • The study 1 highlights the importance of a comprehensive weight loss program that includes monthly contact and support, frequent self-monitoring of body weight, and regular physical activity.
  • Another study, 1, also concludes that there is no clear evidence that nutrition supplements are effective for obesity management or weight loss.
  • A more recent study, 1, reiterates that comprehensive weight loss maintenance programs that provide at least monthly contact with trained individuals and focus on ongoing monitoring of body weight and physical activity are more effective than nutrition supplements.
  • It is essential to prioritize a calorie-controlled diet and regular exercise over supplements, as no supplement alone produces significant weight loss, as noted in 1.

In terms of specific supplements, some studies suggest that:

  • Protein supplements (20-30g per serving) may help preserve muscle mass during weight loss and increase satiety, but this is not a substitute for a comprehensive weight loss program.
  • Soluble fiber supplements like glucomannan (1-2g before meals) may reduce appetite and food intake, but the evidence is limited.
  • Conjugated linoleic acid (CLA) at 3-6g daily may have minor fat-reducing effects, but the evidence is not strong enough to recommend its use.

Overall, the most effective approach to burning fat and achieving weight loss is through a comprehensive program that includes a calorie-controlled diet, regular exercise, and ongoing support and monitoring, rather than relying on supplements.

From the FDA Drug Label

Use for weight loss in overweight adults, 18 years and older, when used along with a reduced-calorie and low-fat diet Directions read the enclosed brochure for other important information diet and exercise are the starting points for any weight loss program. The effective supplement for burning fat is orlistat, which should be used along with a reduced-calorie and low-fat diet and an exercise program for overweight adults, 18 years and older 2 2.

  • Key points:
    • Take 1 capsule with each meal containing fat
    • Do not take more than 3 capsules daily
    • Use with a reduced-calorie, low-fat diet and exercise program until you reach your weight loss goal
    • Most weight loss occurs in the first 6 months.

From the Research

Effective Supplements for Burning Fat

The following supplements have been claimed to increase fat metabolism or energy expenditure:

  • Caffeine: has data to back up its fat metabolism-enhancing properties 3
  • Green tea: has data to back up its fat metabolism-enhancing properties 3
  • Conjugated linoleic acid: although some show some promise, evidence is lacking 3
  • Forskolin: although some show some promise, evidence is lacking 3
  • Chromium: although some show some promise, evidence is lacking 3
  • Kelp: although some show some promise, evidence is lacking 3
  • Fucoxanthin: although some show some promise, evidence is lacking 3

Safety and Efficacy of Fat Burners

The safety and efficacy of fat burners are controversial, with some studies suggesting that they may be effective in stimulating weight loss, while others raise concerns about their safety 4, 5.

  • Ephedra and ephedrine-containing supplements have been singled out due to safety concerns 4
  • The use of fat burners may be associated with risks, including the presence of prohibited substances that are not declared on the label 6

Comparison with Diet and Exercise

Studies have compared the effectiveness of fat burners and thermogenic supplements to diet and exercise for weight loss and cardiometabolic health:

  • Meta-analysis examined pooled effect size and 95% confidence interval for various outcomes, including body mass, fat mass, and cardiometabolic health 7
  • The results suggest that the use of thermogenic dietary supplements may be less effective than diet and exercise in inducing beneficial changes 7

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Fat burners: nutrition supplements that increase fat metabolism.

Obesity reviews : an official journal of the International Association for the Study of Obesity, 2011

Research

Dietary supplements in weight reduction.

Journal of the American Dietetic Association, 2005

Research

Risks associated with fat burners: A toxicological perspective.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2019

Research

The use of dietary supplements by athletes.

Journal of sports sciences, 2007

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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