From the Research
I strongly advise against taking Atarax (hydroxyzine) and Flexeril (cyclobenzaprine) together without medical supervision due to potential additive sedative effects. Both medications are central nervous system depressants that can cause drowsiness, dizziness, and impaired coordination. When combined, these effects may be intensified, increasing the risk of falls and accidents, especially when operating machinery or driving. Additionally, both medications can cause dry mouth, blurred vision, and urinary retention, which could be worsened when taken together.
Key Considerations
- The sedative effects of both medications can be additive, leading to increased risk of accidents and falls 1.
- Both medications can cause anticholinergic side effects, such as dry mouth, blurred vision, and urinary retention, which can be worsened when taken together 2.
- Individual factors, such as age, weight, and existing health conditions, can significantly impact how these medications interact in the body 3.
Recommendations
- If considering using these medications concurrently for muscle spasm and anxiety relief, consult a healthcare provider first to discuss potential risks and benefits.
- Healthcare providers may adjust dosages, recommend taking them at different times of day, or suggest alternative treatments to minimize side effects while maintaining therapeutic benefits.
- Never adjust medication regimens on your own, as this can lead to adverse interactions and decreased therapeutic efficacy 4.
Evidence-Based Guidance
The most recent and highest quality study on the topic of muscle relaxants and their interactions is from 2020 1, which highlights the importance of careful consideration when combining central nervous system depressants. While this study does not specifically address the interaction between hydroxyzine and cyclobenzaprine, it emphasizes the need for medical supervision when using these types of medications together.