What is the cause of thumb pain?

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Last updated: February 26, 2025View editorial policy

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Differential Diagnosis for Thumb Pain

  • Single most likely diagnosis
    • Osteoarthritis: This is a common condition that affects the joints, including the thumb, causing pain and stiffness. The thumb's basal joint is particularly prone to osteoarthritis due to its high mobility and stress.
  • Other Likely diagnoses
    • Trigger thumb: A condition where the tendon sheath surrounding the tendon of the thumb becomes inflamed, causing pain and stiffness, especially when moving the thumb.
    • De Quervain's tenosynovitis: Inflammation of the tendons on the thumb side of the wrist, leading to pain and tenderness, especially when forming a fist or grasping.
    • Thumb sprain: A common injury that can cause pain, swelling, and limited mobility in the thumb.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Infectious arthritis: A bacterial or fungal infection within the joint, which can lead to severe joint damage and systemic infection if not promptly treated.
    • Gout: A form of arthritis characterized by sudden, severe attacks of pain, swelling, redness, and tenderness, often affecting the joints of the hands, including the thumb.
    • Fracture: A break in one of the bones of the thumb, which can be easily overlooked but requires proper treatment to avoid long-term disability.
  • Rare diagnoses
    • Giant cell tumor of the tendon sheath: A rare, benign tumor that can cause pain and swelling in the thumb.
    • Erythromelalgia: A rare disorder characterized by burning pain, heat, and redness in the hands and feet, including the thumbs.
    • Sarcoidosis: A rare autoimmune disease that can cause inflammation and pain in various parts of the body, including the joints of the thumb.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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