What is the minimum time interval to wait before taking Vicodin (hydrocodone) after taking Ambien (zolpidem)?

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Last updated: June 25, 2025 • View editorial policy

From the Research

It is generally recommended to wait at least 6-8 hours after taking Ambien (zolpidem) before taking Vicodin (hydrocodone/acetaminophen). Both medications are central nervous system depressants that can cause respiratory depression, sedation, and impaired cognitive function. Taking them too close together increases the risk of these side effects and can potentially be dangerous. Ambien has a relatively short half-life of about 2-3 hours, meaning that after 6-8 hours, a significant portion of the medication has been cleared from your system 1. However, individual factors such as age, liver function, and other medications can affect how quickly your body processes these drugs.

Some key points to consider:

  • Zolpidem's peak plasma concentration occurs in 45 to 60 minutes, with a terminal elimination half-life of 2.4 hours 1.
  • The extended-release formulation of zolpidem results in a higher concentration over a period of more than 6 hours 1.
  • Hydrocodone/acetaminophen has been shown to be effective in treating pain, but it can also cause significant side effects, particularly when combined with other central nervous system depressants 2.
  • It's essential to follow your doctor's specific instructions regarding timing between these medications, as they may recommend a longer interval based on your personal health situation.

It's crucial to prioritize caution when taking these medications together, as the risk of adverse interactions can be significant. Never adjust the dosing schedule without consulting your healthcare provider, as these are both prescription medications with potential for serious interactions.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.