From the Research
Trimebutine is available in Canada under the brand name Modulon and as generic trimebutine maleate, with a typical cost of $30 to $60 for a one-month supply (100mg tablets, 90-count). The medication is available by prescription only and is used to treat functional gastrointestinal disorders, particularly irritable bowel syndrome (IBS), by regulating gut motility. Trimebutine works as both an antimuscarinic and an agonist of peripheral mu, kappa, and delta opiate receptors, helping to normalize bowel function in patients with either diarrhea or constipation-predominant IBS, as demonstrated in a study published in 2021 1. Some key points to consider about Trimebutine include:
- The standard adult dosage is typically 100-200mg three times daily before meals.
- Side effects are generally mild and may include dizziness, dry mouth, and constipation.
- Trimebutine has been shown to improve symptoms and psychological adjustment to illness in irritable bowel syndrome, as seen in a study from 2006 2.
- The medication's mechanism of action involves an agonist effect on peripheral mu, kappa, and delta opiate receptors and modulation of gastrointestinal peptides release, as described in a 1997 study 3. If you're considering this medication, consult with your healthcare provider to determine if it's appropriate for your specific condition and to get an accurate prescription that would be covered by your particular drug plan.