Is there an extra strength diclofenac (nonsteroidal anti-inflammatory drug (NSAID)) gel prescription available for osteoarthritis?

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Last updated: June 25, 2025View editorial policy

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From the Research

Yes, there is an extra strength diclofenac gel prescription available for osteoarthritis, specifically Diclofenac sodium topical gel 1% (Voltaren Gel), which is available by prescription in a higher strength than the over-the-counter version. For osteoarthritis, the prescription-strength gel is typically applied to the affected joint four times daily, using 2-4 grams per application depending on the size of the joint being treated, as seen in studies such as 1. The maximum recommended daily dose is 32 grams, applied over all affected joints. This topical NSAID works by reducing inflammation and pain directly at the site of application, with less systemic absorption compared to oral NSAIDs, potentially resulting in fewer gastrointestinal side effects, as noted in 2, 3. When using diclofenac gel, it's essential to wash hands before and after application (unless treating hands), avoid applying to broken or irritated skin, and not cover the treated area with bandages. Patients should be aware that even topical NSAIDs carry some risk of cardiovascular events and should discuss with their healthcare provider if they have heart disease, hypertension, or other risk factors, as mentioned in 4, 5.

Some key points to consider when using diclofenac gel for osteoarthritis include:

  • The importance of proper application and dosing to minimize side effects and maximize efficacy, as seen in 1, 2.
  • The potential for local adverse effects, such as skin irritation or allergic reactions, as noted in 4, 3.
  • The need for regular monitoring and follow-up with a healthcare provider to assess treatment response and adjust the treatment plan as needed, as implied in 5.

Overall, diclofenac gel can be a useful treatment option for osteoarthritis, offering a topical alternative to oral NSAIDs with potentially fewer systemic side effects, as supported by studies such as 2, 3.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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