What is the recommended dose of Jardiance (Empagliflozin) for adults with type 2 diabetes?

From the Guidelines

The recommended dose of Jardiance (Empagliflozin) for adults with type 2 diabetes is 10 mg once daily. This dose is based on the most recent and highest quality study, which recommends initiating SGLT2 inhibitors with CV benefit at the lowest dose tested in CV and renal outcomes trials 1. The study notes that no further dose titration is needed for CV or renal risk reduction, but dose increases may provide further glucose reduction benefits if indicated.

Key Considerations

• The medication should be taken in the morning with or without food.
• Patients with kidney impairment may require dose adjustments; specifically, Jardiance should not be initiated if eGFR is below 45 mL/min/1.73 m² for glycemic control, as stated in the 2020 expert consensus decision pathway 1.
• However, a more recent study from 2022 suggests that the use of Empagliflozin is not recommended with eGFR <45 mL/min/1.73 m² 1.
• The medication works by inhibiting sodium-glucose cotransporter-2 (SGLT2) in the kidneys, which prevents glucose reabsorption and increases glucose excretion in urine, thereby lowering blood glucose levels.
• Patients should be advised to stay adequately hydrated while taking Jardiance and to monitor for side effects such as urinary tract infections, genital mycotic infections, and hypoglycemia, especially if they are also taking insulin or insulin secretagogues.
• Regular kidney function monitoring is recommended during treatment.

Important Side Effects and Interactions

• Euglycemic diabetic ketoacidosis is a potential side effect of Empagliflozin, as noted in the study 1.
• The medication may contribute to intravascular volume contraction, and patients should be cautioned about this potential effect 1.
• Patients with prior amputation, severe peripheral neuropathy, severe peripheral vascular disease, or active diabetic foot ulcers or soft tissue infections should use Empagliflozin with caution 1.

From the FDA Drug Label

2.1 Recommended Dosage The recommended dose of JARDIANCE is 10 mg once daily in the morning, taken with or without food. In patients tolerating JARDIANCE, the dose may be increased to 25 mg [see Clinical Studies (14)].

The recommended dose of Jardiance (Empagliflozin) for adults with type 2 diabetes is 10 mg once daily, which can be increased to 25 mg if the patient tolerates it 2.

From the Research

Recommended Dose of Jardiance (Empagliflozin) for Adults with Type 2 Diabetes

The recommended dose of Jardiance (Empagliflozin) for adults with type 2 diabetes is:

• 10 mg once daily, as stated in the study 3
• 25 mg once daily, as mentioned in the studies 3, 4, and 5

Key Considerations

When prescribing Jardiance, consider the following:

• The efficacy of empagliflozin increases according to the level of hyperglycaemia but decreases in patients with renal insufficiency, as noted in the study 3
• Empagliflozin has shown a cardiovascular protection in the EMPA-REG OUTCOME trial, as mentioned in the study 3
• The most common adverse effects of empagliflozin include genital infections, kidney failure, and diabetic ketoacidosis, as reported in the study 6

Dosage Forms and Strengths

Jardiance is available in the following dosage forms and strengths:

• 10 mg tablets, as mentioned in the study 3
• 25 mg tablets, as mentioned in the studies 3, 4, and 5