Differential Diagnosis for 10 Weeks Pregnant with Cramps and Copious Vaginal Bleeding

• Single Most Likely Diagnosis
  • Miscarriage: This is the most likely diagnosis given the symptoms of cramps and copious vaginal bleeding at 10 weeks of pregnancy. Miscarriage is a common complication of early pregnancy, and the symptoms presented are classic for this condition.
• Other Likely Diagnoses
  • Ectopic Pregnancy: Although less common than miscarriage, ectopic pregnancy is a possible cause of vaginal bleeding and cramps in early pregnancy. It occurs when the embryo implants outside the uterus, often in the fallopian tube.
  • Molar Pregnancy: A molar pregnancy is another possible cause, characterized by abnormal growth of the placenta, which can lead to vaginal bleeding and other complications.
• Do Not Miss Diagnoses
  • Placenta Previa: This condition, where the placenta covers the cervix, can cause severe vaginal bleeding and is life-threatening if not promptly diagnosed and managed.
  • Uterine Rupture: Although rare in the first trimester, uterine rupture is a catastrophic event that requires immediate attention. It could be considered in patients with a history of uterine surgery or other risk factors.
• Rare Diagnoses
  • Gestational Trophoblastic Disease (other than molar pregnancy): This includes rare conditions like choriocarcinoma, which can present with vaginal bleeding among other symptoms.
  • Cervical or Uterine Pathology: Conditions such as cervical polyps, uterine fibroids, or cervical cancer could potentially cause vaginal bleeding, though they are less likely to be the primary cause in the context of early pregnancy and cramps.