From the Research
Varenicline is the most cost-effective smoking cessation method in terms of QALYs gained and ICER, as it has been shown to be more effective in maintaining abstinence and reducing craving than bupropion and NRT, with a typical regimen of 0.5mg daily for 3 days, 0.5mg twice daily for 4 days, then 1mg twice daily for 11-12 weeks 1. The cost-effectiveness of smoking cessation methods can be evaluated based on their ability to improve Quality-Adjusted Life Years (QALYs) and their Incremental Cost-Effectiveness Ratio (ICER).
- Varenicline has been shown to be a highly effective treatment for smoking cessation, with a unique mechanism of action that reduces cravings and withdrawal symptoms 2.
- Combination nicotine replacement therapy (NRT) is also a cost-effective option, typically involving a nicotine patch and a faster-acting form like nicotine gum or lozenges 3, 4.
- The cost-effectiveness advantage of these pharmacological approaches stems from relatively low intervention costs compared to the substantial health benefits gained through smoking cessation, including reduced risk of cancer, cardiovascular disease, and respiratory conditions 5, 1.
- Behavioral support is also crucial in improving quit rates, and combining it with pharmacological approaches can lead to even better outcomes 3, 2.
- The most recent study from 2024 found that varenicline seems to be more effective in maintaining abstinence and reducing craving than bupropion and NRT 1. Key points to consider when choosing a smoking cessation method include:
- Efficacy in maintaining abstinence and reducing craving
- Cost-effectiveness, including ICER and QALYs gained
- Tolerability and potential adverse effects
- Combination with behavioral support for improved outcomes
- Individual patient needs and preferences, such as comorbidities and previous quit attempts.