What is the cause of hematuria (blood in urine) and stomach pain?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: February 26, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnosis for Hematuria and Stomach Pain

Single Most Likely Diagnosis

  • Gastrointestinal Bleed: This is the most likely diagnosis as it directly correlates with both hematuria (if the blood is coming from the lower GI tract) and stomach pain. The presence of blood in the urine could be a sign of a severe bleed that has led to blood being visible in the urine, especially if the patient is experiencing significant blood loss.

Other Likely Diagnoses

  • Kidney Stones: These can cause severe stomach or flank pain and hematuria. The pain is often colicky in nature, and the hematuria can range from microscopic to gross.
  • Urinary Tract Infection (UTI): While more commonly associated with dysuria and frequency, a severe UTI, especially pyelonephritis, can cause flank pain and hematuria.
  • Gastritis or Peptic Ulcer Disease: These conditions can cause stomach pain and, if bleeding is present, could potentially lead to hematuria if the bleed is significant enough to affect the urinary system indirectly.

Do Not Miss Diagnoses

  • Abdominal Aortic Aneurysm (AAA): Although less common, an AAA can cause abdominal pain and, if ruptured, could lead to hematuria due to the proximity of the aorta to the kidneys and urinary tract. This is a medical emergency.
  • Ectopic Pregnancy: In women of childbearing age, an ectopic pregnancy can cause abdominal pain and, if ruptured, could lead to internal bleeding that might be mistaken for hematuria.
  • Sepsis: Sepsis from any cause can lead to multi-organ dysfunction, including renal impairment that might result in hematuria, and abdominal pain if the source of infection is intra-abdominal.

Rare Diagnoses

  • Goodpasture Syndrome: A rare autoimmune disease that can cause glomerulonephritis leading to hematuria and, in some cases, abdominal pain due to the systemic nature of the disease.
  • Alport Syndrome: A genetic disorder affecting the type IV collagen in the body, leading to kidney disease, hearing loss, and eye abnormalities. It could present with hematuria, and abdominal pain might be a secondary symptom due to associated conditions.
  • Sickle Cell Disease: While primarily known for causing anemia and pain crises, sickle cell disease can lead to renal complications, including hematuria, and abdominal pain due to sickling crises affecting various organs.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.