What are the treatment options for burning mouth syndrome?

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Last updated: June 26, 2025View editorial policy

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From the Guidelines

Burning mouth syndrome treatment should prioritize gabapentin, high potency topical steroids, or viscous lidocaine for moderate to severe cases, as recommended by the most recent guidelines 1. When managing burning mouth syndrome, it's essential to assess the location and character of pain, rule out odontogenic or mucosal sources, and evaluate the severity of pain and its impact on function. For mild cases, assessing the location and character of pain, ruling out odontogenic or mucosal sources, and evaluating the severity of pain and its impact on function are crucial steps 1.

  • Key considerations in treatment include:
    • Holding immunotherapy for moderate to severe cases
    • Dietary modifications
    • Use of gabapentin, high potency topical steroids (gel or dental paste preferred), or viscous lidocaine
  • The condition often requires a multidisciplinary approach, considering factors such as nerve damage, hormonal changes, dry mouth, or nutritional deficiencies, as noted in other studies 1.
  • Cognitive behavioral therapy can be beneficial for addressing psychological factors associated with burning mouth syndrome, as it is often linked with depression and poor quality of life 1.
  • Treatment typically requires a trial-and-error approach, and most patients need to try several approaches before finding effective symptom relief, which may need to continue long-term as the condition can be chronic.

From the Research

Treatment Options for Burning Mouth Syndrome

The treatment options for burning mouth syndrome (BMS) can be categorized into several approaches, including:

  • Local and systemic treatments to address underlying causes
  • Pharmacological therapies to manage symptoms
  • Alternative therapies to provide relief

Pharmacological Therapies

Pharmacological therapies have been found to be effective in managing BMS symptoms, including:

  • Capsaicin, which has been shown to provide relief of oral burning or pain symptom 2
  • Alpha-lipoic acid, which has been found to be effective in reducing oral burning or pain symptom 2, 3
  • Clonazepam, which has been shown to be effective in reducing burning pain intensity in BMS patients 4, 3, 5
  • Antidepressants, which have been found to be effective in managing BMS symptoms 2
  • Pregabalin, which has been found to be effective in reducing BMS symptoms in some patients 6

Alternative Therapies

Alternative therapies have also been found to be effective in managing BMS symptoms, including:

  • Psychotherapy and behavioral feedback, which can help eliminate BMS symptoms 2
  • Cognitive behavior therapy, which has been found to be effective in both short- and long-term assessment 3
  • Low-level laser therapy, which has been found to be effective in both short- and long-term assessment 3
  • Topical capsaicin, which has been found to be effective in both short- and long-term assessment 3

Treatment Approach

The treatment approach for BMS typically involves a step-wise approach, starting with the removal of potential causes, followed by pharmacological therapies, and finally alternative therapies. Vitamin, zinc, or hormone replacement therapy may be effective for reducing oral burning or pain symptom in some BMS patients with deficiency of the corresponding factor 2.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Burning mouth syndrome: a review and update.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2013

Research

A systematic review of treatment for patients with burning mouth syndrome.

Cephalalgia : an international journal of headache, 2022

Research

An open-label, dose escalation pilot study of the effect of clonazepam in burning mouth syndrome.

Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 1998

Research

Effectiveness of Pregabalin for Treatment of Burning Mouth Syndrome.

Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology, 2019

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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