From the FDA Drug Label
DOSAGE AND ADMINISTRATION Type of Infection Dose Every 24 hours Duration (days) Community Acquired Pneumonia (1.1) 400 mg7 to 14 Uncomplicated Skin and Skin Structure Infections (SSSI) (1.2) 400 mg7 Complicated SSSI (1.3) 400 mg7 to 21 Complicated Intra-Abdominal Infections (1.4) 400 mg5 to 14 Plague (1.5) 400 mg10 to 14 Acute Bacterial Sinusitis (1. 6) 400 mg10 Acute Bacterial Exacerbation of Chronic Bronchitis (1.7) 400 mg5 No dosage adjustment in patients with renal or hepatic impairment. (8.6,8.7)
The recommended dosage of moxifloxacin for adults with normal renal function is 400 mg every 24 hours.
- The duration of treatment varies depending on the type of infection, ranging from 5 to 14 days for community-acquired pneumonia, uncomplicated skin and skin structure infections, and acute bacterial exacerbation of chronic bronchitis, to 7 to 21 days for complicated skin and skin structure infections, and 10 to 14 days for plague and acute bacterial sinusitis.
- No dosage adjustment is necessary for patients with renal or hepatic impairment, including those requiring hemodialysis (HD) or continuous ambulatory peritoneal dialysis (CAPD) 1.
From the Research
The recommended dosage of moxifloxacin for adults is 400 mg once daily, regardless of renal function status. This standard dose applies to patients with normal kidney function as well as those with renal impairment, including patients on hemodialysis or continuous ambulatory peritoneal dialysis. No dose adjustment is necessary for patients with mild, moderate, or severe renal impairment, as supported by studies such as 2 and 3. Moxifloxacin is primarily eliminated through non-renal pathways, which explains why dosage adjustments are not required in renal dysfunction.
The typical duration of treatment depends on the infection being treated, ranging from 5-14 days. Moxifloxacin should be taken at the same time each day with or without food, and patients should maintain adequate hydration during treatment. It's essential to note that moxifloxacin carries a risk of serious adverse effects, including tendinitis, tendon rupture, peripheral neuropathy, and central nervous system effects, so patients should be monitored accordingly during treatment, as highlighted in studies like 4 and 5.
Key points to consider when prescribing moxifloxacin include:
- The drug's efficacy in treating various infections, as demonstrated in studies such as 6
- Its safety profile, which is comparable to other antibiotics, as shown in 2
- The importance of monitoring patients for potential adverse effects, as mentioned in 3
- The convenience of once-daily dosing, which can improve patient compliance, as noted in 4 and 5.
Overall, moxifloxacin is a valuable option for the treatment of various bacterial infections, offering a convenient dosing regimen and a favorable safety profile, as supported by the evidence from 2, 4, 5, 6.