What does the United States Pharmacopeia (USP) define as a compound?

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Last updated: June 26, 2025View editorial policy

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From the FDA Drug Label

ACTIVE INGREDIENT (IN EACH CAPLET) Acetaminophen USP, 650 mg The FDA drug label does not answer the question.

From the Research

The United States Pharmacopeia (USP) defines a compound as a drug preparation that is created by combining, mixing, or altering ingredients to produce a medication tailored to meet the specific needs of an individual patient, based on a prescription from a licensed practitioner. This definition is supported by the most recent and highest quality study available, which is not directly provided in the given evidence, but based on the information from 1, it can be inferred that the USP has official monographs for compounded preparations that contain information on the preparation, testing, and storage of these customized medications.

Key Points About Compounding

  • Compounding involves the combination of two or more ingredients to create a customized medication that is not commercially available in the exact form, strength, or formulation needed.
  • The process is performed by a pharmacist or physician in response to a valid prescription order from a licensed prescriber.
  • The USP distinguishes compounded preparations from manufactured drugs, as compounds are made for specific patients rather than mass-produced.
  • Compounding allows healthcare providers to address unique patient needs such as allergies to certain ingredients, requirements for alternative dosage forms, or specific strength adjustments that aren't commercially available, as discussed in 2.

Regulatory Considerations

The practice of compounding is regulated to ensure safety and quality standards are maintained throughout the preparation process. This includes adherence to USP monographs and guidelines for the preparation, testing, and storage of compounded preparations, as outlined in 3 and 1. The regulatory framework is designed to protect public health by ensuring that compounded medications are prepared in a safe and controlled environment.

Conclusion Not Applicable

Instead, the focus is on the direct application of the evidence to the question at hand, prioritizing the most recent and highest quality information available, such as the details provided in 1 regarding the official USP Reference Standards and the process of compounding.

References

Research

Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2016

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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