From the Guidelines
Rinvoq (upadacitinib) is not directly associated with hypothermia and bradycardia as common side effects, and its impact on these conditions is not clearly established in the provided evidence. The provided study 1 discusses post-resuscitation care and the management of hypothermia and bradycardia in the context of cardiac arrest, but it does not mention Rinvoq or its effects on body temperature or heart rate.
Key Points to Consider
- The study 1 focuses on the European Resuscitation Council and European Society of Intensive Care Medicine guidelines for post-resuscitation care, which does not directly relate to the use of Rinvoq.
- Bradycardia is discussed in the context of mild induced hypothermia as a normal physiological response, and it is associated with a good outcome as long as other vital signs are stable.
- There is no direct evidence in the provided study to suggest that Rinvoq causes hypothermia or bradycardia.
- If a patient taking Rinvoq experiences symptoms of hypothermia or bradycardia, it is essential to consider other potential causes and evaluate whether the medication should be discontinued.
Clinical Implications
- Healthcare providers should be aware of the potential for hypothermia and bradycardia in patients, but they should not automatically attribute these conditions to Rinvoq without considering other possible causes.
- The decision to continue or discontinue Rinvoq in patients experiencing hypothermia or bradycardia should be based on a thorough evaluation of the patient's condition and the potential benefits and risks of the medication.
From the Research
Association of Rinvoq (upadacitinib) with Hypothermia and Bradycardia
There are no research papers to assist in answering this question, as none of the provided studies mention Rinvoq (upadacitinib) in relation to hypothermia and bradycardia.
Hypothermia and Bradycardia in Other Contexts
- Hypothermia and bradycardia have been reported in various medical contexts, including: + Azithromycin treatment 2 + Accidental hypothermia 3 + Glucocorticoid or cyclosporine A therapy in a patient with Kikuchi-Fujimoto disease 4 + Late-onset post-lesional paroxysmal hypothermia 5 + Anti-aquaporin 4 antibody-associated disorder 6
- These studies suggest that hypothermia and bradycardia can be associated with various medical conditions and treatments, but do not provide information on Rinvoq (upadacitinib) specifically.