From the Research
I strongly advise against combining trazodone with methamphetamine as this combination poses serious health risks. Trazodone is a prescription antidepressant medication that affects serotonin levels in the brain, while methamphetamine is an illegal stimulant that increases dopamine and norepinephrine. Using these substances together can cause dangerous cardiovascular effects including irregular heartbeat, extreme blood pressure fluctuations, and increased risk of heart attack or stroke. The combination may also lead to serotonin syndrome, a potentially life-threatening condition characterized by confusion, high fever, seizures, and muscle rigidity. Additionally, the opposing effects of a sedative (trazodone) and stimulant (methamphetamine) place tremendous stress on your body's regulatory systems. If you're prescribed trazodone, you should take it exactly as directed by your healthcare provider and avoid illicit substances. If you're struggling with methamphetamine use, please seek professional help from addiction specialists who can provide appropriate treatment options and support for recovery.
Some key points to consider:
- Trazodone has been shown to be effective in treating major depressive disorder, with a recent study published in 2023 1 highlighting its efficacy and safety.
- The use of trazodone for insomnia has also been studied, with a 2018 review 2 finding that it may be effective in improving sleep quality.
- However, the combination of trazodone with methamphetamine is not supported by any evidence and poses significant health risks.
- It's essential to prioritize your health and well-being by avoiding the use of illicit substances and following the guidance of your healthcare provider.
In terms of the evidence, the most recent and highest-quality study on trazodone was published in 2023 1, which provides valuable insights into its efficacy and safety. While other studies, such as those published in 2012 3 and 2018 2, also provide useful information, the 2023 study is the most relevant and up-to-date. It's essential to rely on the most recent and highest-quality evidence when making decisions about your health, and to consult with a healthcare professional before making any changes to your treatment plan.