From the FDA Drug Label
In acute severe dermatitis due to poison ivy, relief may result within 8 to 12 hours following intramuscular administration of a single dose of 80 to 120 mg.
The appropriate intramuscular (IM) dose of Depo Medrol (methylprednisolone) for a 180-pound male with poison ivy is 80 to 120 mg. This dose is administered as a single injection and may provide relief within 8 to 12 hours 1.
From the Research
For a 180-pound male with poison ivy, the appropriate intramuscular dose of Depo Medrol (methylprednisolone acetate) would typically be 80-120 mg as a single injection, as supported by the most recent and relevant study on poison ivy treatment patterns 2. This dose provides anti-inflammatory effects that help reduce the itching, swelling, and rash associated with poison ivy dermatitis. After administration, the medication will gradually release into the bloodstream over several days, providing extended relief. The injection should be administered deep into a large muscle, such as the gluteal muscle, using proper aseptic technique. Patients should be aware that while relief often begins within 24 hours, it may take 2-3 days for maximum effect. Side effects can include temporary increase in blood glucose, fluid retention, and mood changes. This treatment is most effective when given early in the course of the reaction, and should be accompanied by other measures such as:
- Washing the affected area thoroughly to remove any remaining urushiol (the allergenic oil from the poison ivy plant)
- Using topical treatments for symptom relief A single injection is usually sufficient for most poison ivy reactions, but severe or extensive cases may require additional treatment, as noted in studies on treatment outcomes 2. It's also important to consider the potential for undertreatment, as shorter durations of oral corticosteroids have been associated with increased risk of return visits to healthcare clinicians 2. Therefore, treatment with Depo Medrol should be considered in the context of overall management of poison ivy dermatitis, including patient education on prevention and self-care measures, as well as monitoring for potential complications, such as those reported in cases of severe urushiol exposure 3.