From the Research
Yes, primidone can cause double vision (diplopia) as a side effect. This anticonvulsant medication, commonly used to treat seizure disorders and essential tremor, affects the central nervous system and can impact visual function. Double vision occurs in some patients because primidone influences the neurological pathways that control eye movement and coordination. This side effect typically appears dose-related, meaning it may be more likely to occur at higher doses or when the medication is first started. If you experience double vision while taking primidone, you should contact your healthcare provider promptly rather than discontinuing the medication on your own. Your doctor might consider adjusting your dosage, changing your medication schedule, or switching to an alternative anticonvulsant. The mechanism behind this side effect relates to primidone's action on GABA neurotransmitters in the brain, which can affect the nerves controlling eye muscles. Other visual disturbances that might accompany double vision include blurred vision, nystagmus (involuntary eye movements), or general visual disturbances, as seen in studies such as 1. However, it's essential to note that the provided studies do not directly address the incidence of double vision with primidone, but its potential to cause neurological side effects that could lead to visual disturbances is a consideration in its use, as discussed in 2, 3, 4, and 5. Given the potential for primidone to impact visual function, monitoring for such side effects is crucial when prescribing this medication. In clinical practice, the decision to use primidone must weigh its benefits against potential risks, including those related to visual function, and consider alternative treatments if necessary. The most recent and highest quality study directly relevant to primidone's side effects, including potential visual disturbances, should guide clinical decision-making, although such a study is not explicitly provided in the given evidence. Therefore, it is crucial for patients experiencing double vision or any other visual disturbances while on primidone to seek medical attention to ensure appropriate management and minimize potential long-term effects on vision and overall quality of life.