From the Guidelines
The therapeutic range for tadalafil (Cialis) tablets is 2.5 to 20 mg for erectile dysfunction and benign prostatic hyperplasia, and 40 mg daily for pulmonary arterial hypertension. When considering the treatment of erectile dysfunction, the dosing of tadalafil can vary, with a typical recommended dose of 10 mg taken prior to anticipated sexual activity, not to exceed once daily 1. This dose can be adjusted based on efficacy and tolerability, ranging from 5 mg to a maximum of 20 mg. For daily use in erectile dysfunction, a lower dose of 2.5 to 5 mg once daily is recommended. In the context of benign prostatic hyperplasia, the standard dose is 5 mg once daily. Key points to consider in the therapeutic use of tadalafil include:
- The medication's mechanism of action as a phosphodiesterase type 5 inhibitor, which enhances blood flow by relaxing smooth muscles.
- Peak plasma concentrations are reached within 2 hours, and the drug has a half-life of approximately 17.5 hours, contributing to its prolonged action compared to other erectile dysfunction medications.
- Potential interactions with nitrates, alpha-blockers, and certain antihypertensive medications, which could lead to significant hypotension. Given the information from the study 1, it's clear that tadalafil, at a dose of 40 mg daily, is also utilized in the treatment of pulmonary arterial hypertension, highlighting its versatility in managing different conditions.
From the FDA Drug Label
The recommended starting dose of tadalafil tablets for use as needed in most patients is 10 mg, taken prior to anticipated sexual activity. The dose may be increased to 20 mg or decreased to 5 mg, based on individual efficacy and tolerability. The recommended starting dose of tadalafil tablets for once daily use is 2.5 mg, taken at approximately the same time every day, without regard to timing of sexual activity. The tadalafil tablets dose for once daily use may be increased to 5 mg, based on individual efficacy and tolerability.
The therapeutic ranges for tadalafil (Cialis) tablets are:
- For use as needed: 5 mg to 20 mg, with a maximum recommended dosing frequency of once per day in most patients 2
- For once daily use: 2.5 mg to 5 mg, taken at approximately the same time every day, without regard to timing of sexual activity 2
From the Research
Therapeutic Ranges for Tadalafil (Cialis) Tablets
The therapeutic ranges for tadalafil (Cialis) tablets are as follows:
- The recommended dose of tadalafil for erectile dysfunction is 10 mg taken prior to anticipated sexual activity, with a maximum frequency of once daily 3.
- Tadalafil is also available in a once-daily formulation, with doses of 2.5 mg and 5 mg, which can be taken without regard to timing of sexual activity 4, 5.
- The efficacy and safety of tadalafil have been evaluated in several studies, with doses ranging from 2 mg to 25 mg 4, 6, 3, 7.
Efficacy of Tadalafil
The efficacy of tadalafil has been demonstrated in several studies, including:
- A multicenter, randomized, double-blind, placebo-controlled trial that evaluated the efficacy and safety of once-a-day dosing of tadalafil 5 mg and 10 mg in the treatment of erectile dysfunction 4.
- A study that evaluated the efficacy of tadalafil in non-responders to sildenafil and vardenafil, which found that tadalafil 20 mg significantly improved erectile function in these patients 6.
- A study that evaluated the efficacy of tadalafil once daily in men with erectile dysfunction who had previously demonstrated a partial response to as-needed sildenafil, tadalafil, or vardenafil, which found that tadalafil once daily provided similar efficacy to as-needed PDE5I therapy 7.
Safety of Tadalafil
The safety of tadalafil has been evaluated in several studies, with common adverse events including: