From the Guidelines
Yes, ceftriaxone (Rocephin) can be administered as an inpatient, as it is commonly used in hospital settings for various infections, including pneumonia, meningitis, intra-abdominal infections, skin infections, and urinary tract infections. The typical adult dosage ranges from 1-2 grams once or twice daily, usually given intravenously or intramuscularly, as seen in the guidelines for infective endocarditis 1. For severe infections, doses up to 4 grams daily may be used. Ceftriaxone is particularly valuable in inpatient settings due to its long half-life allowing for once-daily dosing in many cases, which improves convenience and potentially reduces nursing time.
Some key points to consider when administering ceftriaxone in an inpatient setting include:
- Monitoring for potential side effects, including hypersensitivity reactions, gastrointestinal disturbances, and possible interactions with calcium-containing products, as noted in various guidelines 1.
- Assessing renal and hepatic function before and during treatment, with dosage adjustments made for patients with severe renal impairment, as recommended in the guidelines for valvular heart disease 1.
- Considering the use of ceftriaxone in combination with other antibiotics for certain types of infections, such as endocarditis or meningitis, as outlined in the guidelines for infective endocarditis 1 and meningitis 1.
Overall, ceftriaxone is a valuable antibiotic in the inpatient setting, and its use should be guided by current clinical guidelines and the specific needs of the patient, as supported by the most recent and highest quality studies, such as those published in Circulation 1 and the Journal of Infection 1.
From the FDA Drug Label
Intravenous Administration Ceftriaxone for injection should be administered intravenously by infusion over a period of 30 minutes, except in neonates where administration over 60 minutes is recommended to reduce the risk of bilirubin encephalopathy.
Yes, ceftriaxone (Rocephin) can be administered as an inpatient, and it is recommended to be administered intravenously by infusion over a period of 30 minutes, except in neonates.
- The usual adult daily dose is 1 to 2 grams given once a day (or in equally divided doses twice a day) depending on the type and severity of infection.
- The total daily dose should not exceed 4 grams. 2
From the Research
Administration of Ceftriaxone (Rocephin) as an Inpatient
- Ceftriaxone can be administered as an inpatient for the treatment of severe bacteremic infections, as demonstrated in a study published in 1989 3.
- The study found that a single daily dose of ceftriaxone was effective in treating severe bacteremic infections in non-neutropenic adult patients.
- Ceftriaxone has a broad spectrum of activity against Gram-positive and Gram-negative aerobic, and some anaerobic, bacteria, making it a suitable option for inpatient treatment of various infections 4.
- The drug can be administered intravenously or intramuscularly, and its long half-life allows for once-daily administration in most adults 4, 5, 6.
- Ceftriaxone has been shown to be effective in treating various types of infections, including:
- Urinary tract infections
- Lower respiratory tract infections
- Skin and soft tissue infections
- Bacteremia/septicaemia
- Paediatric meningitis
- Adult meningitis
- The efficacy and safety of ceftriaxone have been demonstrated in several studies, including those published in 1984 4, 1991 5, 6, and 1984 7.