From the Research
For alternatives to Proactive Support from TYLENOL, consider supplements containing glucosamine and chondroitin, which have been shown to be effective in reducing pain and improving function in osteoarthritis patients, with a cost of around $20 for a 30-day supply. The most recent and highest quality study, 1, a systematic review and meta-analysis, found that the combination of glucosamine and chondroitin is effective and superior to other treatments in knee osteoarthritis, with a significant advantage in reducing pain and improving function. Another study, 2, a critical review, also found that pharmacologic-grade chondroitin sulfate supplements may have clinically significant benefits in osteoarthritis treatment.
- Key ingredients to look for in alternatives include glucosamine and chondroitin, which have been shown to have synergistic effects in reducing pain and inflammation.
- When choosing an alternative, consider the quality of the supplement, as the therapeutic effects of glucosamine and chondroitin may depend on the source of origin, purity, and contamination with by-products, as noted in 2.
- Always check with your healthcare provider before switching supplements, especially if you have underlying health conditions.
- The recommended dosing for glucosamine and chondroitin is typically 500-1500 mg and 400-1200 mg daily, respectively, as noted in 3 and 4.