Is Terbinafine (antifungal medication) used for treating acne?

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From the Guidelines

No, terbinafine is not used for treating acne. Terbinafine is an antifungal medication primarily used to treat fungal infections such as athlete's foot, jock itch, ringworm, and fungal nail infections. Acne is caused by a combination of factors including excess oil production, bacteria (specifically Cutibacterium acnes, formerly known as Propionibacterium acnes), inflammation, and clogged pores—not by fungi. For acne treatment, medications such as benzoyl peroxide, salicylic acid, retinoids (like tretinoin or adapalene), or antibiotics (like clindamycin or doxycycline) are typically prescribed depending on the severity, as recommended by recent guidelines 1. These treatments target the specific causes of acne by reducing oil production, killing bacteria, reducing inflammation, or helping with cell turnover. Using terbinafine for acne would be ineffective because it targets fungal pathogens and would not address any of the underlying causes of acne.

Some key points to consider in acne treatment include:

  • The use of benzoyl peroxide, topical retinoids, and topical antibiotics as first-line treatments for mild to moderate acne 1.
  • The recommendation for oral doxycycline in cases of moderate to severe acne 1.
  • The importance of limiting systemic antibiotic use to reduce the risk of antibiotic resistance and other complications 1.
  • The consideration of alternative treatments such as spironolactone, combined oral contraceptives, and isotretinoin in specific cases 1.

Overall, the treatment of acne should be tailored to the individual patient's needs and severity of symptoms, and should prioritize evidence-based treatments that target the underlying causes of the condition.

From the Research

Terbinafine and Acne Treatment

  • Terbinafine is an antifungal medication, and its primary use is not for treating acne 2, 3.
  • The provided studies focus on the use of terbinafine for fungal infections, such as onychomycosis and dermatophyte infections 2, 3.
  • There is no mention of terbinafine being used to treat acne in the provided studies 4, 5, 2, 3, 6.
  • Studies 4 and 5 discuss the treatment of acne, but they do not mention terbinafine as a treatment option.
  • The treatment options for acne discussed in the studies include benzoyl peroxide, antibiotics, and azelaic acid 4, as well as antimicrobial agents such as erythromycin, clindamycin, and tetracycline 5.

Conclusion Not Applicable

As per the given instructions, a conclusion section should not be included.

Evidence Summary

  • The studies provided do not support the use of terbinafine for treating acne 4, 5, 2, 3, 6.
  • Terbinafine is effective against fungal infections, but its use for acne treatment is not mentioned in the studies 2, 3.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Terbinafine: a review of its use in onychomycosis in adults.

American journal of clinical dermatology, 2003

Research

[Acne therapy with topical benzoyl peroxide, antibiotics and azelaic acid].

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2006

Research

Current issues in antimicrobial therapy for the treatment of acne.

Journal of the European Academy of Dermatology and Venereology : JEADV, 2001

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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